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dc.contributor.advisorVasskog, Terje
dc.contributor.advisorHansen, Espen
dc.contributor.advisorAndersen, Jeanette H.
dc.contributor.authorKorsmo, Kim André
dc.date.accessioned2012-07-03T10:12:15Z
dc.date.available2012-07-03T10:12:15Z
dc.date.issued2012-05
dc.description.abstractIn the marine environment there is a great potential for discovering new commercial drugs, and marine bioprospecting has previously led to the discovery of drugs available for clinical use, like Yondelis ® and cytosine arabinoside. In this work two hydroids were tested for anticancer and antibacterial activity. The organic extracts from the two hydroids, Halecium muricatum and Halecium beanii, showed activity in the 1st and 2nd screening against the human melanoma cell line and Streptococcus group B. This resulted in dereplication and isolation of eight possible bioactive compounds. After the isolation, the two purest compounds were analyzed using TOF- MS, 1H- NMR, 13C- NMR, HMBC combined with HSQC NMR and MS- MS for structure elucidation. From the structure elucidation it was obvious that the two compounds were phosphocholines, however the exact structures were not confirmed. These two compounds were tested against human melanoma, normal lung fibroblasts, breast cancer and prostate cancer for confirmation of bioactivity.en
dc.identifier.urihttps://hdl.handle.net/10037/4327
dc.identifier.urnURN:NBN:no-uit_munin_4046
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2012 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDFAR-3901en
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Analytisk kjemi: 445en
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Analytical chemistry: 445en
dc.titleIsolation and characterization of bioactive compounds from the marine hydrozoans Halecium muricatum and Halecium beaniien
dc.typeMaster thesisen
dc.typeMastergradsoppgaveen


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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)