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dc.contributor.authorHaavind, Anniken
dc.contributor.authorHevrøy, Olav
dc.contributor.authorHennig, rune
dc.contributor.authorBjertnæs, Lars J.
dc.date.accessioned2012-12-17T09:18:14Z
dc.date.available2012-12-17T09:18:14Z
dc.date.issued2011
dc.description.abstractPneumonia, severe sepsis, and acute respiratory distress syndrome (ARDS) are frequent complications after head trauma. Recombinant human activated protein C (APC) reportedly improves circulation and respiration in severe sepsis, but is contraindicated after head injury because of increased risk of intracranial bleeding. A 21-year-old man with severe head injury after a car accident was endotracheally intubated, mechanically ventilated, and hemodynamically stabilized before transfer to our university hospital. His condition became complicated with pneumonia, septic shock, ARDS, coagulation dysfunction, and renal failure. In spite of intensive therapy, oxygenation and arterial blood pressure fell to critically low values. Simultaneously, his intracranial pressure peaked and his pupils dilated, displaying no reflexes to light. His antibiotic regimen was changed and ventilation was altered to high frequency oscillations, and despite being ethically problematic, we added APC to his treatment. The patient recovered with modest neurological sequelae.en
dc.identifier.citationInternational Medical Case Reports Journal 4(2011) s. 41-46en
dc.identifier.cristinIDFRIDAID 873796
dc.identifier.doiDOI: 10.2147/IMCRJ.S21249
dc.identifier.issn1179-142X
dc.identifier.urihttps://hdl.handle.net/10037/4679
dc.identifier.urnURN:NBN:no-uit_munin_4391
dc.language.isoengen
dc.publisherDove Pressen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Traumatology: 783en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Traumatologi: 783en
dc.titleControversial treatment of a victim of severe head injury complicated by septic shock and acute respiratory distress syndromeen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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