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dc.contributor.authorManiaol, Angelina
dc.contributor.authorElsais, Ahmed
dc.contributor.authorLorentzen, Åslaug Rudjord
dc.contributor.authorOwe, Jone Furulund
dc.contributor.authorViken, Marte K
dc.contributor.authorSæther, Hanne Skarpodde
dc.contributor.authorFlåm, Siri Tennebø
dc.contributor.authorBråthen, Geir
dc.contributor.authorKampman, Margitta Theodora
dc.contributor.authorMidgard, Rune
dc.contributor.authorChristensen, Marte
dc.contributor.authorRognerud, Anna Kaja
dc.contributor.authorKerty, Emilia
dc.contributor.authorGilhus, Nils Erik
dc.contributor.authorTallaksen, Chantal
dc.contributor.authorLie, Benedicte Alexandra
dc.contributor.authorHarbo, Hanne Flinstad
dc.date.accessioned2013-03-07T12:14:21Z
dc.date.available2013-03-07T12:14:21Z
dc.date.issued2012
dc.description.abstractAcquired myasthenia gravis (MG) is a rare antibody-mediated autoimmune disease caused by impaired neuromuscular transmission, leading to abnormal muscle fatigability. The aetiology is complex, including genetic risk factors of the human leukocyte antigen (HLA) complex and unknown environmental factors. Although associations between the HLA complex and MG are well established, not all involved components of the HLA predisposition to this heterogeneous disease have been revealed. Well-powered and comprehensive HLA analyses of subgroups in MG are warranted, especially in late onset MG. This case-control association study is of a large population-based Norwegian cohort of 369 MG patients and 651 healthy controls. We performed comprehensive genotyping of four classical HLA loci (HLA-A, -B, -C and -DRB1) and showed that the DRB1*15:01 allele conferred the strongest risk in late onset MG (LOMG; onset ≥60years) (OR 2.38, pc7.4×10−5). DRB1*13:01 was found to be a protective allele for both early onset MG (EOMG) and LOMG (OR 0.31, pc 4.71×10−4), a finding not previously described. No significant association was found to the DRB1*07:01 allele (pnc = 0.18) in a subset of nonthymomatous anti-titin antibody positive LOMG as reported by others. HLA-B*08 was mapped to give the strongest contribution to EOMG, supporting previous studies. The results from this study provide important new information concerning the susceptibility of HLA alleles in Caucasian MG, with highlights on DRB1*15:01 as being a major risk allele in LOMG.en
dc.identifier.citationPLoS ONE (2012) 7(5): e36603en
dc.identifier.cristinIDFRIDAID 945091
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0036603
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/4906
dc.identifier.urnURN:NBN:no-uit_munin_4623
dc.language.isoengen
dc.publisherPublic Library of Science (PLoS)en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Tropical medicine: 761en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Tropemedisin: 761en
dc.titleLate onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian populationen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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