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dc.contributor.authorLe, Viet
dc.contributor.authorNguyen, Thi Ngoc Lan
dc.contributor.authorTy, Phung Xuan
dc.contributor.authorBjørkvoll, Bjørn
dc.contributor.authorHoel, Hedda B
dc.contributor.authorGutteberg, Tore Jarl
dc.contributor.authorHusebekk, Anne
dc.contributor.authorLarsen, Stig
dc.contributor.authorSkjerve, Eystein
dc.contributor.authorHusum, Hans
dc.date.accessioned2013-03-13T12:24:27Z
dc.date.available2013-03-13T12:24:27Z
dc.date.issued2012
dc.description.abstractSafe blood and blood products should be offered to all patients in need for blood transfusion. The objectives of the present study were to establish prevalence estimates for hepatitis B and hepatitis C virus infections as a foundation for safe blood transfusion in rural Vietnam, and to check the accuracy of the laboratory analysis used for hepatitis testing of blood donors in Vietnam. A cross-sectional study was conducted in two rural communities in Quang Tri, Vietnam. A total of 1,200 blood samples collected from potential blood donors were tested by an enzyme immunoassay technique (EIA) for detection of hepatitis surface antigen (HBsAg), antibodies to hepatitis B core antigen (anti-HBc), and antibodies to hepatitis C antigen (anti-HCV). The EIA test outcome was validated by a chemiluminescent micro particle immunoassay technique (CMIA). Results: The prevalence of HBsAg and anti-HBc in the study population was 11.4 per cent (95% CI 9.6 - 13.2) and 51.7 per cent (95% CI 48.8 - 54.5), respectively, the prevalences being higher in males than females. The prevalence of anti-HCV was 0.17 per cent. The test agreement between the EIA and CMIA techniques was high both for HBsAg detection (κ = 0.91; 95% CI: 0.83 - 0.99) and for anti-HBc detection (κ = 0.89; 95% CI 0.81 - 0.97). Compared to CMIA results, the positive and negative predictive values of the EIA tests were found to be 94.9 per cent (95% CI 87.5 - 98.6) and 97.5 per cent (95% CI 86.8 - 99.9) for HBsAg, and 92.4 per cent (95% CI 84.2 - 97.2) and 100 per cent (95% CI 91.2 - 100) for anti-HBc. Interpretation & conclusions: The study shows that hepatitis B virus infection is endemic in rural areas of Vietnam and that almost half of the population is or has been infected. Hepatitis C infection is rare, but false negative test results cannot be ruled out. Also, the results indicate that the EIA performance in blood donor screening in Vietnam may be sub-optimal, missing 2.5 per cent of hepatitis B virus carriers and falsely excluding more than 7 per cent of blood donors. As the prevalence of hepatitis B infection is high, occult hepatitis B infection may represent a threat to safe blood transfusion. Therefore, nucleic acid amplification testing for HBV should be considered for blood donor screening in Vietnam.en
dc.descriptionThis article is part of Viet Le's doctoral thesis which is available in Munin at <a href=http://hdl.handle.net/10037/6970>http://hdl.handle.net/10037/6970</a>en
dc.identifier.citationIndian Journal of Medical Research (IJMR) 136(2012) nr. 1 s. 74-81en
dc.identifier.cristinIDFRIDAID 947820
dc.identifier.issn0971-5916
dc.identifier.urihttps://hdl.handle.net/10037/4992
dc.identifier.urnURN:NBN:no-uit_munin_4678
dc.language.isoengen
dc.publisherIndian Council of Medical Researchen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en
dc.titlePrevalence of hepatitis B & hepatitis C virus infections in potential blood donors in rural Vietnamen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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