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dc.contributor.authorMurphy, Neil
dc.contributor.authorNorat, Teresa
dc.contributor.authorFerrari, Pietro
dc.contributor.authorJenab, Mazda
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorSkeie, Guri
dc.contributor.authorDahm, Christina C.
dc.contributor.authorOvervad, Kim
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjønneland, Anne
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorBoutron-Ruault, Marie Christine
dc.contributor.authorRacine, Antoine
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorTeucher, Birgit
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBergmann, Manuela M.
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorLagiou, Pagona
dc.contributor.authorPalli, Domenico
dc.contributor.authorPala, Valeria
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorSiersema, Peter D.
dc.contributor.authorvan Duijnhoven, Fränzel J.B.
dc.contributor.authorPeeters, Petra H M
dc.contributor.authorHjartåker, Anette
dc.contributor.authorEngeset, Dagrun
dc.contributor.authorGonzalez, Carlos A.
dc.contributor.authorSánchez, Maria-José
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorNavarro, Camen
dc.contributor.authorArdanaz, Eva
dc.contributor.authorQuirós, José R.
dc.contributor.authorSonestedt, Emily
dc.contributor.authorEricson, Ulrika
dc.contributor.authorNilsson, Lena
dc.contributor.authorPalmqvist, Richard
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nick
dc.contributor.authorKey, Timothy J.
dc.contributor.authorCrowe, Francesca L.
dc.contributor.authorFedirko, Veronika
dc.contributor.authorWark, Petra A.
dc.contributor.authorChuang, Shu-Chun
dc.contributor.authorRiboli, Eilo
dc.date.accessioned2013-03-13T14:44:19Z
dc.date.available2013-03-13T14:44:19Z
dc.date.issued2012
dc.description.abstractEarlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. After a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79–0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals. Our results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.en
dc.identifier.citationPLoS ONE (2012), vol.7(6): e39361en
dc.identifier.cristinIDFRIDAID 960338
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0039361
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/5008
dc.identifier.urnURN:NBN:no-uit_munin_4710
dc.language.isoengen
dc.publisherPublic Library of Science (PLoS)en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.titleDietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and Nutrition (EPIC)en
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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