Now showing items 1-20 of 740

    • Can Individual Placement and Support (IPS) contribute to change the life of individuals experiencing mental health problems? Challenges related to Efficacy, Effectiveness, and Implementation 

      Brinchmann, Beate (Doctoral thesis; Doktorgradsavhandling, 2025-03-07)
      Mental health problems are leading cause of disability in Western societies, with a rising proportion due to mental health problems among young people. Employment is beneficial for health and well-being and is a human right for all. Employment is a key goal for individuals with severe mental health problems, and the vocational rehabilitation approach, Individual Placement and Support (IPS), has ...
    • Toddlers’ imitation and understanding of communicative intentions in various social contexts - The role of social partner type and ostension on toddlers’ imitation and their inferences about communicative intentions 

      Flatebø, Solveig (Doctoral thesis; Doktorgradsavhandling, 2025-02-28)
      Children are innately adapted to socialize with their caregivers and environment. In the first years of life, they engage in social learning through interactions with others, for instance, by observing and imitating behaviors. They learn most effectively when adults communicate ostensively with them, using eye contact, infant-directed speech, or contingent responsivity. They may even faithfully ...
    • Female sex hormones and subtypes of breast cancer 

      Busund, Marit Katinka (Doctoral thesis; Doktorgradsavhandling, 2025-02-20)
      Bakgrunn: Det er gode holdepunkter for at kvinnelige kjønnshormoner har en avgjørende rolle i utviklingen av brystkreft. Subtyper av brystkreft utgjør distinkte sykdomsentiteter og har ulik etiologi, risikofaktorer og prognoser. Disse subtypene er ofte klassifisert som luminal A-lignende, luminal B-lignende, HER2-positiv og trippel-negativ brystkreft (TNBC) basert på immunhistokjemisk undersøkelse. ...
    • MRI in musculoskeletal inflammatory disease in children, with a focus on technique, standardisation and findings 

      Tanturri de Horatio, Laura (Doctoral thesis; Doktorgradsavhandling, 2025-02-07)
      Inflammatory musculoskeletal (MSK) diseases are common among children and adolescents, with early diagnosis and treatment crucial for long-term outcomes. Magnetic resonance imaging (MRI) has become a key tool in guiding treatment due to the challenges of clinical assessment of disease activity. However, there is a lack of validated, child-specific MRI tools for monitoring these diseases. This ...
    • Modern corneal imaging technology in cataract and refractive surgery -Total corneal astigmatism and corneal epithelial thickness measurements for surgical planning in lens exchange- and laser vision correction surgery 

      Feng, Yue (Doctoral thesis; Doktorgradsavhandling, 2025-01-24)
      <p><i>Background/Aim:</i> The precision and accuracy of corneal imaging technology are crucial in contemporary cataract and refractive surgery. This thesis aims to assess the repeatability and agreement of measurements for total corneal astigmatism (TCA), axial length (AL) and corneal epithelial thickness mapping (ETM) using five modern optical coherence tomography (OCT) devices across various ...
    • Novel Molecular Characteristics of Ulcerative Colitis 

      Meng, Wei (Doctoral thesis; Doktorgradsavhandling, 2025-01-10)
      Ulcerative Colitis (UC) is a chronic autoimmune inflammatory disease and one type of inflammatory bowel disease (IBD). UC is characterized by a temporal course of remission and relapse. Environmental factors, immune system dysregulation, and genetic susceptibility interact intricately in the aetiology of UC. It is unclear how interactions involving non-coding RNAs (ncRNAs), epigenetic modifications, ...
    • Prevalence of obesity and its associations with other cardiovascular risk factors in Russia. Insights from the Know Your Heart Study 

      Kholmatova, Kamila (Doctoral thesis; Doktorgradsavhandling, 2024-12-16)
      <p><i>Background.</i> The prevalence of obesity has reached epidemic proportions worldwide. Obesity is a risk factor for the development of cardiovascular disease (CVD) and predisposes to hypertension, type 2 diabetes mellitus (T2D) and dyslipidemia. The simultaneous presence of visceral adiposity and these cardiometabolic disorders, also known as the metabolic syndrome, accelerates atherosclerotic ...
    • COVID-19 morbidity, severity, and mortality in a population-based sample of adults in Arkhangelsk, Northwest Russia 

      Krieger, Ekaterina (Doctoral thesis; Doktorgradsavhandling, 2024-12-12)
      <p><i>Objective</i> To investigate seroprevalence, spectrum of COVID-19 cases and factors associated with COVID-19 morbidity, severity, and mortality in a population-based sample of adults in Arkhangelsk, Northwest Russia. <p><i>Methods</i> Participants in the Know Your Heart study (2015-2017) were enrolled in a COVID-19 seroprevalence study (n=1348) in 2021 and followed up for COVID-19 diagnosis, ...
    • Who skis where, when? 

      Toft, Håvard Boutera (Doctoral thesis; Doktorgradsavhandling, 2024-12-12)
      <p>Backcountry skiing has emerged as a so-called adventure sport in recent decades and has had a considerable social and economic impact in Northern Norway. Tourism, Norway's fifth-largest export industry, is experiencing significant growth and is especially important for small communities. However, recreation in avalanche terrain comes at a cost due to the risk of avalanches. Consequently, any ...
    • FKRP-related limb-girdle muscular dystrophy R9 in Norway – Studies of epidemiology, natural history, and relationships with health-related quality of life and sleep 

      Jensen, Synnøve (Doctoral thesis; Doktorgradsavhandling, 2024-12-06)
      <p><i>Background/aims:</i> Limb-girdle muscular dystrophy R9 (LGMDR9) is a rare autosomal recessive muscle disease caused by mutations in the fukutin-related protein gene, FKRP. The prevalence is higher in northern European populations, where it is closely associated with the FKRP c.826CA allele. This work aims to study the epidemiology of LGMDR9 in Norway, natural history, and relationships with ...
    • Functionally impaired children and their caregivers: A study in a clinical neuropaediatric setting on validity and usefulness of screening instruments completed by caregivers, and caregivers' satisfaction with neuropaediatric assessment 

      Kjærandsen, Katarina Maria Smejda (Doctoral thesis; Doktorgradsavhandling, 2024-12-06)
      This dissertation is based on a naturalistic multicentre study in the context of an interdisciplinary assessment in neuropediatric clinics. The main objective was to expand knowledge about this assessment, focusing primarily on the role of screening instruments completed by caregivers and their satisfaction with the assessment. The validity and usefulness of screening tools for parental mental health ...
    • The Tumor Immune Microenvironment as a Regulator of Oral Cancer Progression 

      Sellæg, Kjersti (Doctoral thesis; Doktorgradsavhandling, 2024-12-05)
      Oral squamous cell carcinoma (OSCC) is a growing global health concern, particularly among the younger population. The immune system plays an important role in tumor progression and a high density of tumor infiltrating T lymphocytes is linked to improved patient prognosis and therapy response. Tumor-associated high endothelial venules (TA-HEVs) facilitate lymphocyte entry into tumors via the ...
    • A conceptual model for implementing pharmacist services in primary care settings. Exploring a novel healthcare service in a Norwegian Home Care Setting 

      Bø, Karl-Erik (Doctoral thesis; Doktorgradsavhandling, 2024-12-06)
      <p><i>Background:</i> Global aging increases the number of frail and multi-morbid patients, thereby raising the total volume of healthcare consultations. Furthermore, people aged 65 and over are more prone to medication errors and adverse drug events. This situation strains resources in healthcare settings and poses a challenge to healthcare systems and healthcare workers. To meet these challenges, ...
    • Microbial evolution in biofilms 

      Lorentzen, Øyvind Myrvoll (Doctoral thesis; Doktorgradsavhandling, 2024-12-06)
      Formation of biofilms is an important adaptive strategy that bacteria employ to endure challenging conditions. This thesis delves into the evolution of the pathogen <i>Vibrio cholerae</i> in biofilms with a focus on biofilm adaptation, c-di-GMP signaling and β-lactamase evolution. Paper 1 improved upon the genome of <i>V. cholerae</i> C6706 and linked every open reading frame to the current reference ...
    • Renal Sympathetic Denervation. Quality of Life, Hypertensive Heart Disease and Biomarker Discovery 

      Subbotina, Anna (Doctoral thesis; Doktorgradsavhandling, 2024-12-05)
      Hypertension, which affects about one-third of adults worldwide, is a leading cause of heart disease, stroke, and kidney failure. Despite the known benefits of lowering blood pressure, control remains inadequate worldwide. Only half of those with hypertension are aware of their condition, and even fewer receive adequate treatment. Among those treated, many do not achieve target blood pressure levels. ...
    • Differences in risk of venous thromboembolism in men and women 

      Arnesen, Carl Arne Løchen (Doctoral thesis; Doktorgradsavhandling, 2024-11-22)
      Venous thromboembolism (VTE) is a common and potentially deadly disease that affects men and women, but studies on sex-specific risk have been inconsistent. Some studies have reported a higher risk in men, others in women. It has also been suggested that men have a higher inherent risk of VTE than women when reproductive factors (pregnancy and estrogen use) are accounted for. Furthermore, the ...
    • Mental Health Problems, General Health and Dropout in Upper Secondary School in Northern Norway: A prospective cohort study and a qualitative exploration of the dropout process 

      Goll, Charlotte Bjørnskov (Doctoral thesis; Doktorgradsavhandling, 2024-11-22)
      Health and socioeconomic inequalities are heavily correlated, and poor mental health increases the risk of exclusion from the labour market. Education is important to equalize the socioeconomic gradient, and completing upper secondary school is essential. The high dropout rates in upper secondary school are therefore of high concern. The main project “Ung vilje” was a prospective cohort study started ...
    • Neonatal risk factors for hearing impairment 

      Hemmingsen, Dagny Elise (Doctoral thesis; Doktorgradsavhandling, 2024-11-01)
      Hearing impairment (HI) is a prevalent childhood disability with significant public health implications, impacting language and developmental outcomes if not early identified and managed. While illness in the neonatal period is a recognized risk factor for HI, less is known about the specific impacts of the different, and often interrelated morbidities and invasive treatments in neonatal intensive ...
    • Maternal death and maternal morbidity in Georgia 

      Skhvitaridze, Natia (Doctoral thesis; Doktorgradsavhandling, 2024-10-25)
      Maternal death (MD) and morbidity are indicators for maternal health and healthcare system development. This PhD project aimed to investigate MD, maternal morbidity, and related risk factors in Georgia using data from the Georgian Birth Registry (GBR) and digital health surveillance systems. Paper I, with a case series design, identified direct and indirect causes of MD from 2014 to 2017. Paper ...
    • Child-Inclusive Mandatory Family Mediation in Norway: A sociocultural exploration of children’s participation 

      Grape, Lovise (Doctoral thesis; Doktorgradsavhandling, 2024-10-11)
      <p><i>Introduction:</i> Family mediation should help separating parents make agreements that attend to the best interest of the child. Children can be included in this process. The aim of this dissertation is to explore the practise of child-inclusive family mediation in Norway on three interdependent planes: a personal, an interpersonal, and a cultural and institutional plane. These planes follow ...