English
norskDesign, Synthesis and Biological Activity of Small α-Aminoboron Containing Peptidomimetics
Permanent link
https://hdl.handle.net/10037/5145
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Thesis introduction (PDF)
Tore Lejon, Olga V. Gozhina and Victor N. Khrustalev: '(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-2-phenyl-4,6-methano-1,3,2-benzodioxaborole', Acta Crystallographica Section E (2012), E68, o3103. Available at http://dx.doi.org/10.1107/S1600536812041712 (PDF)
Date
2013-01-18Type
Doctoral thesisDoktorgradsavhandling
Abstract
Antimicrobial peptides (AMPs) are a special group of small amphipathic peptides
(which hold both hydrophilic and hydrophobic regions) composed of different amino acids
and produced by all living organisms as a part of innate immunity. With the increasing
microbial resistance to traditional antibiotics the need for unconventional therapeutic has
become crucial.
This thesis deals with the design and synthesis of a library of α-aminoboronic di- and
tri- peptides and investigation of their biological activity against different bacteria strains,
fungi and kinases in order to discover compounds that can further be developed into drugs.
Preliminary results have provided a broad spectrum of data regarding structure-activity
relationship of synthesized peptides and several new potential therapeutics have been
discovered.
Description
Papers 1, 2, 4 and 5 are not available in Munin:
1. Olga V. Gozhina, Ivar K. Thomassen and Tore Lejon: 'Ultrasound promoted dimerization of benzylic halides' (accepted manuscript in Synthetic Communications).
2. Alexey S. Gorovoy, Olga V. Gozhina, John Sigurd Svendsen, Anna A. Domorad, George V. Tetz, Victor V. Tetz and Tore Lejon: 'Boron containing peptidomimetics – a novel class of selective anti-tubercular drugs', (accepted manuscript in Chemical Biology & Drug Design).
4. Alexey S. Gorovoy, Olga V. Gozhina, John Sigurd Svendsen, George V. Tetz, Anna A. Domorad, Victor V. Tetz and Tore Lejon: 'Synthesis and anti-tubercular activity of β-substituted and α,β-disubstituted β-aminoboronates and boronic acids' (manuscript).
5. Olga V. Gozhina, John Sigurd Svendsen and Tore Lejon: 'Synthesis and antimicrobial activity of α-aminoboronic containing peptidomimetics' (manuscript)
1. Olga V. Gozhina, Ivar K. Thomassen and Tore Lejon: 'Ultrasound promoted dimerization of benzylic halides' (accepted manuscript in Synthetic Communications).
2. Alexey S. Gorovoy, Olga V. Gozhina, John Sigurd Svendsen, Anna A. Domorad, George V. Tetz, Victor V. Tetz and Tore Lejon: 'Boron containing peptidomimetics – a novel class of selective anti-tubercular drugs', (accepted manuscript in Chemical Biology & Drug Design).
4. Alexey S. Gorovoy, Olga V. Gozhina, John Sigurd Svendsen, George V. Tetz, Anna A. Domorad, Victor V. Tetz and Tore Lejon: 'Synthesis and anti-tubercular activity of β-substituted and α,β-disubstituted β-aminoboronates and boronic acids' (manuscript).
5. Olga V. Gozhina, John Sigurd Svendsen and Tore Lejon: 'Synthesis and antimicrobial activity of α-aminoboronic containing peptidomimetics' (manuscript)
Publisher
Universitetet i TromsøUniversity of Tromsø
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