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dc.contributor.authorAndersen, Toril
dc.contributor.authorVanic, Zeljka
dc.contributor.authorFlaten, Gøril Eide
dc.contributor.authorMattsson, S.
dc.contributor.authorTho, Ingunn
dc.contributor.authorSkalko-Basnet, Natasa
dc.date.accessioned2013-12-10T07:24:24Z
dc.date.available2013-12-10T07:24:24Z
dc.date.issued2013
dc.description.abstractMucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method. The pectin- and chitosan-containing liposomes, namely pectosomes and chitosomes, were prepared by the modified solvent injection method. In order to optimize this novel delivery system, we used pectins and chitosans of both high and low degree of esterification/deacetylation (DE/DD), respectively. Sonication was applied to reduce the original vesicle size. All vesicles were characterized for their size, zeta potential, metronidazole entrapment, and stability. Both pectosomes and chitosomes were found to entrap more metronidazole than conventional plain liposomes. Preliminary data indicate that the polymer is present on the liposomal surface, embedded within inner liposomal bilayers, and entrapped inside the aqueous compartment. The next step in the evaluation of this system is the testing of its mucoadhesiveness.en
dc.identifier.citationPharmaceutics 5(2013) s. 445-456en
dc.identifier.cristinIDFRIDAID 1047562
dc.identifier.doihttp://dx.doi.org/10.3390/pharmaceutics5030445
dc.identifier.issn1999-4923
dc.identifier.urihttps://hdl.handle.net/10037/5590
dc.identifier.urnURN:NBN:no-uit_munin_5289
dc.language.isoengen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440::Pharmaceutical chemistry: 448en
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448en
dc.titlePectosomes and Chitosomes as Delivery Systems for Metronidazole: The One-Pot Preparation Methoden
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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