Browsing Artikler, rapporter og annet (medisinsk biologi) by Title
Now showing items 1003-1022 of 1054
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Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-05)Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date. The lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1), a specific lymphatic marker, is associated with poor survival in OSCC patients. In this study, we present a potential ... -
Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Perturbed action of signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways, is one of the hallmarks of many cancers. While the implication of the typical MAP kinase pathways ERK1/2-MEK1/2, p38MAPK and JNK is well established, recent findings illustrate that the atypical MAP kinase ERK3/4-MK5 may also be involved in tumorigenic processes. Remarkably, the ERK3/4-MK5 ... -
Tuning of Liver Sieve: The Interplay between Actin and Myosin Regulatory Light Chain Regulates Fenestration Size and Number in Murine Liver Sinusoidal Endothelial Cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-30)Liver sinusoidal endothelial cells (LSECs) facilitate the efficient transport of macromolecules and solutes between the blood and hepatocytes. The efficiency of this transport is realized via transcellular nanopores, called fenestrations. The mean fenestration size is 140 ± 20 nm, with the range from 50 nm to 350 nm being mostly below the limits of diffraction of visible light. The cellular ... -
The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-05)Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health. Failure of these control mechanisms may lead to damaged mitochondria that represent a threat to cell survival. Mitophagy is a selective autophagy process that removes damaged mitochondria ... -
Understanding unexpected courses of multiple sclerosis among patients using complementary and alternative medicine : A travel from recipient to explorer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Understanding variation in primary medical care: a nine-country qualitative study of clinicians' accounts of the non-clinical factors that shape antibiotic prescribing decisions for lower respiratory tract infection.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)There is a wide variation between European countries in antibiotic prescribing for patients in primary care with lower respiratory tract infection (LRTI) that is not explained by case mix and clinical factors alone. Variation in antibiotic prescribing that is not warranted by differences in illness and clinical presentation may increase selection of resistant organisms, contributing to the problem ... -
Unemployment and disability pension-an 18-year follow-up study of a 40-year-old population in a Norwegian county
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)This study explored the association of unemployment and an increased risk of receiving disability pension, and the possibility that this risk is attributed to municipality-specific characteristics. A cohort of 7,985 40-42 year olds was followed for 18 years in national registers, identifying new episodes of unemployment and cases of disability pension. The association between an unemployment period ... -
Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: towards a common nomenclature
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-02)Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and ... -
Updates on old and weary haematopoiesis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-29)Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow create a specific niche or microenvironment where HSCs nest that allows them to retain their unique characteristics and respond rapidly to external stimuli. Ageing is accompanied ... -
Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)Chemotherapy resistance frequently drives tumor progression. Increased expression of ST8SIA4 has been reported in diverse carcinomas and highly correlates with leukemia multidrug resistance (MDR). MicroRNAs (miRNA) are widely recognized as key players in cancer progression and drug resistance. Here, to explore whether miRNA modulates the sensitivity of chronic myelocytic leukemia (CML) to chemotherapeutic ... -
Urokinase Plasminogen Activator Receptor (uPAR) and Plasminogen Activator Inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage Oral Squamous Cell Carcinomas (OSCC)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Use of bodily sensations as a risk assessment tool: Exploring people with Multiple Sclerosis' views on risks of negative interactions between herbal medicine and conventional drug therapies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Use of Complementary and Alternative Medicine Among Patients: Classification Criteria Determine Level of Use
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008)Background and objectives: Self-reported use of complementary and alternative medicine (CAM) among patients varies widely between studies, possibly because the definition of a CAM user is not comparable. This makes it difficult to compare studies. The aim of this study is to present a six-level model for classifying patients' reported exposure to CAM. Prayer, physical exercise, special diets, ... -
Use of complementary and alternative medicine at Norwegian and Danish hospitals
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Several studies have found that a high proportion of the population in western countries use complementary and alternative medicine (CAM). However, little is known about whether CAM is offered in hospitals. The aim of this study was to describe to what extent CAM is offered in Norwegian and Danish hospitals and investigate possible changes in Norway since 2001. A one-page questionnaire was sent ... -
Use of Health care in the main area of Sami habitation in Norway : catching up with national expenditure rates
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)For many years political and professional concerns have centred on the health service access of Norway’s modern Indigenous Sami people. Thirty years ago, a study determined that a low rate of health expenditure on Sami patients had lead to inferior health services for the Sami people, with their average consultation rate 6 times lower than the Norwegian national average. Since 1980, there have been ... -
Use of Peptide Arrays for Identification and Characterization of LIR Motifs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-05)The mammalian ATG8 proteins (LC3A-C/GABARAP, GABARAPL1, and GABARAPL2) are small ubiquitin-like proteins critically involved in macroautophagy. Their processed C-termini are posttranslationally conjugated to a phosphatidylethanolamine moiety, enabling their insertion into the lipid bilayers of both the inner and outer membranes of the forming autophagosomes. The ATG8s bind a diverse selection of ... -
Usefulness of C-reactive protein testing in acute cough/respiratory tract infection: An open cluster-randomized clinical trial with C-reactive protein testing in the intervention group
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
The usefulness of immunohistochemistry in tissue microarrays of Human Papillomavirus negative adenocarcinoma of the uterine cervix
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Utvidet egenmelding : en vei mot riktigere sykefravær?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2009)