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dc.contributor.authorHedberg, Annica
dc.contributor.authorJohansen, Steinar
dc.date.accessioned2014-03-20T14:51:03Z
dc.date.available2014-03-20T14:51:03Z
dc.date.issued2013
dc.description.abstractGroup I introns are a distinct class of RNA self-splicing introns with an ancient origin. All known group I introns present in eukaryote nuclei interrupt functional ribosomal RNA genes located in ribosomal DNA loci. The discovery of the Tetrahymena intron more than 30 years ago has been essential to our understanding of group I intron catalysis, higher-order RNA structure, and RNA folding, but other intron models have provided information about the biological role. Nuclear group I introns appear widespread among eukaryotic microorganisms, and the plasmodial slime molds (myxomycetes) contain an abundance of self-splicing introns. Here, we summarize the main conclusions from previous work on the Tetrahymena intron on RNA self-splicing catalysis as well as more recent work on myxomycete intron biology. Group I introns in myxomycetes that represent different evolutionary stages, biological roles, and functional settings are discussed.en
dc.identifier.citationMobile DNA 4:17(2013)en
dc.identifier.cristinIDFRIDAID 1044477
dc.identifier.doihttp://dx.doi.org/10.1186/1759-8753-4-17
dc.identifier.issn1759-8753
dc.identifier.urihttps://hdl.handle.net/10037/6006
dc.identifier.urnURN:NBN:no-uit_munin_5710
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical molecular biology: 711en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical microbiology: 715en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715en
dc.titleNuclear group I introns in self-splicing and beyonden
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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