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dc.contributor.authorKaneva, Anastasiya M.
dc.contributor.authorBojko, Evgeny
dc.contributor.authorPotolitsyna, Natalya N.
dc.contributor.authorOdland, Jon Øyvind
dc.date.accessioned2014-03-20T15:19:15Z
dc.date.available2014-03-20T15:19:15Z
dc.date.issued2013
dc.description.abstractBackground: Apolipoprotein-E (apoE) is one of the metabolically active apoproteins and plays an important role in lipid metabolism. However, there are no data on levels of apoE in residents of the North in spite of the fact that specific features of lipid metabolism in the northerners are described. The present work was designed to study plasma levels of apoE in residents of the European North of Russia. Methods: A total of 937 native residents of the European North of Russia (463 men and 474 women) aged 13–60 years were included in the study. ApoE concentrations in the blood plasma were measured by immunoturbidimetric method. Results: Plasma levels of apoE in residents of the European North of Russia were low. ApoE concentrations below the defined normal values were detected in 57.0% of the men and in 59.2% of the women. The mean plasma levels of apoE did not significantly differ in men and women (2.80 mg/dl vs 2.87 mg/dl). Plasma apoE concentrations in residents of the European North of Russia changed with age. Plasma levels of apoE decreased from 13 to 21 years in men and from 13 to 35 years in women and then increased in both sexes (p < 0.001). Conclusion: The limits of variation of plasma apoE levels in residents of the European North of Russia shift towards lower values. Plasma levels of apoE below normal values were observed in approximately half of investigation subjects.en
dc.identifier.citationLipids in Health and Disease (2013), vol. 12:43en
dc.identifier.cristinIDFRIDAID 1037407
dc.identifier.doihttp://dx.doi.org/10.1186/1476-511X-12-43
dc.identifier.issn1476-511X
dc.identifier.urihttps://hdl.handle.net/10037/6018
dc.identifier.urnURN:NBN:no-uit_munin_5717
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.titlePlasma levels of apolipoprotein-E in residents of the European North of Russiaen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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