Show simple item record

dc.contributor.authorMurphy, Neil
dc.contributor.authorNorat, Teresa
dc.contributor.authorFerrari, Pietro
dc.contributor.authorJenab, Mazda
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorSkeie, Guri
dc.contributor.authorOlsen, Anja
dc.contributor.authorTjønneland, Anne
dc.contributor.authorDahm, Christina C.
dc.contributor.authorOvervad, Kim
dc.contributor.authorBoutron-Ruault, Marie Christine
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorNailler, Laura
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorTeucher, Birgit
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBergmann, Manuela M.
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorPalli, Domenico
dc.contributor.authorPala, Valeria
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorPanico, Salvatore
dc.contributor.authorPeeters, Petra H.M.
dc.contributor.authorDik, Vincent K.
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorLund, Eiliv
dc.contributor.authorGarcia, José Ramon Quiros
dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorPérez, Maria José Sánches
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorNavarro, Carmen
dc.contributor.authorArdanaz, Eva
dc.contributor.authorManjer, Jonas
dc.contributor.authorAlmquist, Martin
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorPalmqvist, Richard
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nick
dc.contributor.authorKey, Timothy J.
dc.contributor.authorCrowe, Francesca L.
dc.contributor.authorFedirko, Veronika
dc.contributor.authorGunter, Mark J.
dc.contributor.authorRiboli, Elio
dc.date.accessioned2014-03-20T15:25:01Z
dc.date.available2014-03-20T15:25:01Z
dc.date.issued2013
dc.description.abstractBackground: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for individual dairy products with differing fat contents. Materials and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations between intakes of total milk and milk subtypes (whole-fat, semi-skimmed and skimmed), yoghurt, cheese, and dietary calcium with colorectal cancer risk amongst 477,122 men and women. Dietary questionnaires were administered at baseline. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for relevant confounding variables. Results: During the mean 11 years of follow-up, 4,513 incident cases of colorectal cancer occurred. After multivariable adjustments, total milk consumption was inversely associated with colorectal cancer risk (HR per 200 g/day 0.93, 95% CI: 0.89–0.98). Similar inverse associations were observed for whole-fat (HR per 200 g/day 0.90, 95% CI: 0.82–0.99) and skimmed milk (HR per 200 g/day 0.90, 95% CI: 0.79–1.02) in the multivariable models. Inverse associations were observed for cheese and yoghurt in the categorical models; although in the linear models, these associations were non-significant. Dietary calcium was inversely associated with colorectal cancer risk (HR per 200 mg/day 0.95, 95% CI: 0.91–0.99); this association was limited to dairy sources of calcium only (HR per 200 mg/day 0.95, 95% CI: 0.91–0.99), with no association observed for non-dairy calcium sources (HR per 200 mg/day 1.00, 95% CI: 0.81–1.24). Conclusions: Our results strengthen the evidence for a possible protective role of dairy products on colorectal cancer risk. The inverse associations we observed did not differ by the fat content of the dairy products considered.en
dc.identifier.citationPLoS ONE 8(2013) nr. 9:e72715 s. -en
dc.identifier.cristinIDFRIDAID 1075296
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0072715
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/6021
dc.identifier.urnURN:NBN:no-uit_munin_5692
dc.language.isoengen
dc.publisherPublic Library of Science (PLoS)en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.titleConsumption of dairy products and colorectal cancer in the European prospective investigation into cancer and nutrition (EPIC)en
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


File(s) in this item

Thumbnail
Thumbnail

This item appears in the following collection(s)

Show simple item record