Blar i tittel Artikler, rapporter og annet (klinisk medisin)

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    • Glucosamine exposure reduces proteoglycan synthesis in primary human endothelial cells in vitro 

      Reine, Trine M.; Jenssen, Trond Geir; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-23)
      <b>Purpose:</b> Glucosamine (GlcN) supplements are promoted for medical reasons, for example, for patients with arthritis and other joint-related diseases. Oral intake of GlcN is followed by uptake in the intestine, transport in the circulation and thereafter delivery to chondrocytes. Here, it is postulated to have an effect on synthesis and turnover of extracellular matrix constituents expressed ...

    • Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) – an ex vivo study with blood from a C5-deficient individual 

      Hardersen, Randolf Inge; Enebakk, Terje; Christiansen, Dorte; Bergseth, Grete; Brekke, Ole-Lars; Mollnes, Tom Eirik; Lappegård, Knut Tore; Hovland, Anders (Journal article; Tidsskriftartikkel, 2018)
      The aim of the study was to investigate the role of complement factor 5 (C5) in reactions elicited by plasma separation using blood from a C5‐deficient (C5D) individual, comparing it to C5‐deficient blood reconstituted with C5 (C5DR) and blood from healthy donors. Blood was circulated through an <i>ex vivo</i> plasma separation model. Leukocyte CD11b expression and leukocyte–platelet conjugates were ...

    • Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995 

      Søgaard, Anne-Johanne; Magnus, Jeanette H.; Bjørnerem, Åshild; Holvik, Kristin; Ranhoff, Anette Hylen; Emaus, Nina; Meyer, Haakon E; Strand, Bjørn Heine (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-25)
      <p><i>Summary - </i>In 50–79-year-olds who participated in the Tromsø Study (1994–1995), the risk of non-vertebral osteoporotic fractures during 15 years follow-up increased by 22% in men and 9% in women per 1 SD lower grip strength. The strongest association was observed in men aged 50–64 years. <p><i>Introduction - </i>We aimed to explore whether low grip strength was associated with increased ...

    • Group mentorship for undergraduate medical students—a systematic review 

      Skjevik, Elise; Boudreau, J. Donald; Ringberg, Unni; Schei, Edvin; Stenfors, Terese; Kvernenes, Monika; Ofstad, Eirik Hugaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-20)
      <p><i>Introduction - </i>Mentoring has become a prevalent educational strategy in medical education, with various aims. Published reviews of mentoring report very little on group-based mentorship programs. The aim of this systematic review was to identify group-based mentorship programs for undergraduate medical students and describe their aims, structures, contents and program evaluations. Based ...

    • Group-based multimodal physical therapy in women with chronic pelvic pain: A randomized controlled trial 

      Nygaard, Ane Sigrid; Rydningen, Mona Birgitte; Stedenfeldt, Mona; Wojniusz, Slawomir; Larsen, Marthe; Lindsetmo, Rolv-Ole; Haugstad, Gro Killi; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-09)
      <p><i>Introduction - </i>Chronic pelvic pain in women is a complex condition, and physical therapy is recommended as part of a broader treatment approach. The objective of this study was to compare structured group‐based multimodal physical therapy in a hospital setting (intervention group) with primary‐care physical therapy (comparator group) for women with chronic pelvic pain. <p><i>Material and ...

    • Growing up with chronic arthritis: the confusing matter of classification 

      Nordal, Ellen Berit; Guillaume-Czitrom, Severine; Sibilia, Jean (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-09)
      Disease classification in rheumatology is a matter of debate, in paediatrics between International League Against Rheumatism (ILAR) classification ‘pros and cons’, as well as between paediatric and adult rheumatologists. Indeed, there is no consensus yet about how we should name the disease of adults with juvenile idiopathic arthritis (JIA) in childhood. The non-concordance of adult and paediatric ...

    • Growing up with parental substance use disorder: The struggle with complex emotions, regulation of contact, and lack of professional support 

      Wangensteen, Turid; Bramness, Jørgen Gustav; Halsa, Astrid Dagmar (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-20)
      The aim of the study was to explore young people's perceptions and reflections about growing up with parents who have substance use disorder (SUD). In qualitative inter-views with 12 young people (aged 13–26) and in an interpretative phenomenological analysis, we investigated their experiences of everyday life, of the relationships with the parents with SUD, and of conversations about this, both ...

    • Growth and neurodevelopment in very preterm infants receiving a high enteral volume-feeding regimen - a population-based cohort study 

      Klingenberg, Claus; Muraas, Fredrik Kragh; Isaksen, Catherine Elde; Nilsen, Tina; Torgersen, Marte; Melum-Hansen, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-06)
      <i>Aim</i>: The aim of this study is to evaluate a feeding regimen routinely providing >180 ml/kg/d fortified human milk to very preterm infants and impact on in-hospital growth, osteopenia, and neurodevelopment.<p> <p><i>Method</i>: Retrospective population-based descriptive study of infants <30-week gestation admitted within 24 h of birth and discharged during the 6-year period 2005–2010. ...

    • Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19 

      Trøseid, Marius; Holter, Jan Cato; Holm, Kristian; Vestad, Beate; Sazonova, Taisiia; Granerud, Beathe Kiland; Dyrhol-Riise, Anne Ma; Holten, Aleksander Rygh; Tonby, Kristian; Kildal, Anders Benjamin; Heggelund, Lars; Tveita, Anders Aune; Bøe, Simen; Müller, Karl Erik; Jenum, Synne; Hov, Johannes Espolin Roksund; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-23)
      Background - Gut microbiota alterations have been reported in hospitalized COVID-19 patients, with reduced alpha diversity and altered microbiota composition related to respiratory failure. However, data regarding gut microbiota and mortality are scarce.<p> <p>Methods - Rectal swabs for gut microbiota analyses were collected within 48 h after hospital admission (baseline; n = 123) and three-month ...

    • GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility 

      Eriksson, Daniel; Røyrvik, Ellen Christine; Aranda-Guillen, Maribel; Berger, Amund Holte; Landegren, Nils; Artaza, Haydee; Hallgren, Åsa; Grytaas, Marianne; Strøm, Sara; Bratland, Eirik; Botusan, Ileana; Oftedal, Bergithe Eikeland; Breivik, Lars Ertesvåg; Vaudel, Marc; Helgeland, Øyvind; Falorni, Alberto; Jørgensen, Anders Palmstrøm; Hulting, Anna-Lena; Svartberg, Johan; Ekwall, Olov; Fougner, Kristian J; Wahlberg, Jeanette; Nedrebø, Bjørn Gunnar; Dahlqvist, Per; Study group, Norwegian Addison Registry; Study Group, Swedish Addison Registry; Knappskog, Per Morten; Wolff, Anette Susanne Bøe; Bensing, Sophie; Johansson, Stefan; Kämpe, Olof; Husebye, Eystein Sverre (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-11)
      Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first genome-wide association study on AAD, which identifies nine independent risk loci (P < 5 × 10−8). In addition to loci implicated in lymphocyte function and development shared with other ...

    • GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification 

      Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila; González, Karla Sofia Gutiérrez; Balkhiyarova, Zhanna; Faggian, Alessia; Maina, Jared G.; Chen, Shiqian; Todorov, Petar V.; Sharapov, Sodbo; David, Alessia; Marullo, Letizia; Mägi, Reedik; Rujan, Roxana-Maria; Ahlqvist, Emma; Thorleifsson, Gudmar; Gao, Ηe; Εvangelou, Εvangelos; Benyamin, Beben; Scott, Robert A.; Isaacs, Aaron; Zhao, Jing Hua; Willems, Sara M.; Johnson, Toby; Gieger, Christian; Grallert, Harald; Meisinger, Christa; Müller-Nurasyid, Martina; Strawbridge, Rona J.; Goel, Anuj; Rybin, Denis; Albrecht, Eva; Jackson, Anne U.; Stringham, Heather M.; Corrêa, Ivan R.; Farber-Eger, Eric; Steinthorsdottir, Valgerdur; Uitterlinden, André G.; Munroe, Patricia B.; Brown, Morris J.; Schmidberger, Julian; Holmen, Oddgeir Lingaas; Thorand, Barbara; Hveem, Kristian; Wilsgaard, Tom; Mohlke, Karen L.; Wang, Zhe; Shmeliov, Aleksey; den Hoed, Marcel; Loos, Ruth J. F.; Kratzer, Wolfgang; Haenle, Mark; Koenig, Wolfgang; Boehm, Bernhard O.; Tan, Tricia M.; Tomas, Alejandra; Salem, Victoria; Barroso, Inês; Tuomilehto, Jaakko; Boehnke, Michael; Florez, Jose C.; Hamsten, Anders; Watkins, Hugh; Njølstad, Inger; Wichmann, H.-Erich; Caulfield, Mark J.; Khaw, Kay-Tee; van Duijn, Cornelia M.; Hofman, Albert; Wareham, Nicholas J.; Langenberg, Claudia; Whitfield, John B.; Martin, Nicholas G.; Montgomery, Grant; Scapoli, Chiara; Tzoulaki, Ioanna; Elliott, Paul; Thorsteinsdottir, Unnur; Stefansson, Kari; Brittain, Evan L.; McCarthy, Mark I.; Froguel, Philippe; Sexton, Patrick M.; Wootten, Denise; Groop, Leif; Dupuis, Josée; Meigs, James B.; Deganutti, Giuseppe; Demirkan, Ayse; Pers, Tune H.; Reynolds, Christopher A.; Aulchenko, Yurii S.; Kaakinen, Marika A.; Jones, Ben; Prokopenko, Inga (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-07)
      Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without ...

    • Hand grip strength and risk of incident venous thromboembolism: The Tromsø study 

      Leknessund, Oda; Morelli, Vania Maris; Strand, Bjørn Heine; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-04)
      <p><b> Background</b> Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). <p><b> Objectives</b> We aimed to investigate the association between HGS and risk of incident VTE in a population-based ...

    • Hand grip strength in venous thromboembolism: risk of recurrence and mortality 

      Leknessund, Oda; Morelli, Vania Maris; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Background - There is limited information on the relationship between muscle strength and recurrence and mortality after incident venous thromboembolism (VTE).<p> <p>Objectives - To investigate whether weak hand grip strength (HGS) was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.<p> <p>Methods - Participants from the Tromsø Study ...

    • Hands-free continuous carotid Doppler ultrasound for detection of the pulse during cardiac arrest in a porcine model 

      Faldaas, Bjørn Ove; Nielsen, Erik Waage; Storm, Benjamin; Lappegård, Knut Tore; How, Ole-Jakob; Nilsen, Bent Aksel; Kiss, Gabriel Hanssen; Skogvoll, Eirik; Torp, Hans; Ingul, Charlotte Ingeborg Björk (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
      Background/Purpose - Pulse palpation is an unreliable method for diagnosing cardiac arrest. To address this limitation, continuous hemodynamic monitoring may be a viable solution. Therefore, we developed a novel, hands-free Doppler system, RescueDoppler, to detect the pulse continuously in the carotid artery.<p> <p>Methods - In twelve pigs, we evaluated RescueDoppleŕs potential to measure blood ...

    • Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients 

      Dupont, Laust; Eide, Ivar Anders; Hartmann, Anders; Christensen, Jeppe Hagstrup; Åsberg, Anders; Jenssen, Trond Geir; Krarup, Henrik; Svensson, My Hanna Sofia (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-22)
      Background:<br> Cardiovascular disease is the leading cause of death in renal transplant recipients (RTRs). An association between haptoglobin genotype 2 - 2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied. <br>Methods:<br> In this single centre ...

    • Have Changes in Systemic Treatment Improved Survival in Patients with Breast Cancer Metastatic to the Brain? 

      Nieder, Carsten; Marienhagen, Kirsten; Dalhaug, Astrid; Norum, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-07-16)
      Newly developed systemic treatment regimens might lead to improved survival also in the subgroup of breast cancer patients that harbour brain metastases. In order to examine this hypothesis, a matched pairs analysis was performed that involved one group of patients, which were treated after these new drugs were introduced, and one group of patients, which were treated approximately 10 years earlier. ...

    • Head to head comparison of two commercial fecal calprotectin kits as predictor of Mayo endoscopic sub-score and mucosal TNF expression in ulcerative colitis 

      Goll, Rasmus; Heitmann, Richard; Moe, Øystein Kittel; Katrine, Carlsen; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-02)
      <i>Background</i> - Fecal calprotectin is widely used to monitor disease activity in patients with inflammatory bowel disease. Multiple commercial kits exist, however, since the analyses are not standardized, these kits cannot be used interchangeably. We aimed to perform a technical evaluation of two kits (Calpro from Calprolab, Norway and Calprest from Eurospital, Italy) and perform a tuning for ...

    • Headache patients' satisfaction with telemedicine: a 12-month follow-up randomized non-inferiority trial 

      Müller, Kai Ivar; Alstadhaug, Karl Bjørnar; Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-21)
      Background and purpose: We investigated non-acute headache patients’ long-term satisfaction with a telemedicine consultation and consultation preferences in northern Norway. We hypothesized that patients were not less satisfied with telemedicine than traditional consultations. We also examined the influence of gender, age and education on satisfaction. <br> <br> Methods: For 2.5 years, patients ...

    • Healing in the Sami North 

      Sexton, Randall Harold; Stabbursvik, Ellen Anne Buljo (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Health characteristics associated with chemsex among men who have sex with men: Results from a cross-sectional clinic survey in Norway 

      Amundsen, Eirik; Haugstvedt, Åse; Skogen, Vegard; Berg, Rigmor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-05)
      Background Chemsex typically involves drugs such as GHB/GBL, crystal meth and mephedrone, and is increasingly common among MSM. The behaviour has been found to be associated with sexually transmitted infections (STIs) and mental health problems. We aimed to assess the extent of chemsex engagement and associations with different aspects of health, among MSM attending a free specialist walk-in clinic ...