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norskBrowsing Artikler, rapporter og annet (klinisk medisin) by Title
Now showing items 1414-1433 of 1796
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Recombinant human activated protein C ameliorates oleic acid-induced lung injury in awake sheep
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-11-20)Introduction: Acute lung injury (ALI) may arise both after sepsis and non-septic inflammatory conditions and is often associated with the release of fatty acids, including oleic acid (OA). Infusion of OA has been used extensively to mimic ALI. Recent research has revealed that intravenously administered recombinant human activated protein C (rhAPC) is able to counteract ALI. Our aim was to ... -
Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-08-15)Introduction: Acute lung injury often complicates severe sepsis. In Gram-negative sepsis, bacterial endotoxin activates both coagulation and inflammation. Enhanced lung vascular pressures and permeability, increased extravascular lung water content and deteriorated gas exchange characterize ovine endotoxin-induced lung injury, a frequently used model of acute lung injury. Recombinant human ... -
Recurrent venous thromboembolism and bleeding with extended anticoagulation: the VTE-PREDICT risk score
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-17)Aims Deciding to stop or continue anticoagulation for venous thromboembolism (VTE) after initial treatment is challenging, as individual risks of recurrence and bleeding are heterogeneous. The present study aimed to develop and externally validate models for predicting 5-year risks of recurrence and bleeding in patients with VTE without cancer who completed at least 3 months of initial treatment, ... -
Recursive partitioning analysis of systemic therapy after radiotherapy in patients with brain metastases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03)Purpose: The purpose of this study was to identify factors associated with the initiation or continuation of systemic treatment after brain irradiation. The outcome of interest was a utilization rate of at least 75%, given that active extracranial disease is common in patients with brain metastases. If left untreated, extracranial disease limits survival, regardless of successful local treatment of ... -
Red cell distribution width and carotid atherosclerosis progression: The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-29)Red cell distribution width (RDW), a measure of the size variability of circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with progression of atherosclerotic plaques in subjects recruited from the general population. Baseline characteristics, including RDW, were collected from 4677 participants in the fourth survey ... -
Red cell distribution width is associated with future risk of incident stroke. The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-20)Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth ... -
Red Cell Distribution Width Is Associated With Incident Myocardial Infarction in a General Population: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Redefining clinical venous thromboembolism phenotypes: a novel approach using latent class analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-22)Background - Patients with venous thromboembolism (VTE) are commonly classified by the presence or absence of provoking factors at the time of VTE to guide treatment decisions. This approach may not capture the heterogeneity of the disease and its prognosis.<p> <p>Objectives - To evaluate clinically important novel phenotypic clusters among patients with VTE without cancer and to explore their ... -
Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-12)<i>Objectives</i>. The inflammatory response to on-pump cardiac surgery is well known. Systemic inflammatory response syndrome after transcatheter valve implantation (TAVI) has been reported. The objective of this study was to study the inflammatory response during TAVI, and compare with the response during surgical aortic valve replacement. <i>Methods</i>. Eighteen patients undergoing transcatheter ... -
Reducing unwarranted variation: can a ‘clinical dashboard’ be helpful for hospital executive boards and top-level leaders?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)Background/aim: In the past decades, there has been an increasing focus on defining, identifying and reducing unwarranted variation in clinical practice. There have been several attempts to monitor and reduce unwarranted variation, but the experience so far is that these initiatives have failed to reach their goals. In this article, we present the initial process of developing a safety, quality and ... -
Reduction in mental distress among substance users receiving inpatient treatment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Reflections on measuring disordered thoughts as expressed via language
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-06)Thought disorder, as inferred from disorganized and incoherent speech, is an important part of the clinical presentation in schizophrenia. Traditional measurement approaches essentially count occurrences of certain speech events which may have restricted their usefulness. Applying speech technologies in assessment can help automate traditional clinical rating tasks and thereby complement the ... -
Reflections on the nature of measurement in language-based automated assessments of patients' mental state and cognitive function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)Modern advances in computational language processing methods have enabled new approaches to the measurement of mental processes. However, the field has primarily focused on model accuracy in predicting performance on a task or a diagnostic category. Instead the field should be more focused on determining which computational analyses align best with the targeted neurocognitive/psychological functions ... -
Reflections on the nature of measurement in language-based automated assessments of patients' mental state and cognitive function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)Modern advances in computational language processing methods have enabled new approaches to the measurement of mental processes. However, the field has primarily focused on model accuracy in predicting performance on a task or a diagnostic category. Instead the field should be more focused on determining which computational analyses align best with the targeted neurocognitive/psychological functions ... -
Reflections on the nature of measurement in language-based automated assessments of patients' mental state and cognitive function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)Modern advances in computational language processing methods have enabled new approaches to the measurement of mental processes. However, the field has primarily focused on model accuracy in predicting performance on a task or a diagnostic category. Instead the field should be more focused on determining which computational analyses align best with the targeted neurocognitive/psychological functions ... -
Refleksjon og læring i et aksjonsrettet fagutviklingsprosjekt : erfaringer fra et samarbeid mellom studenter, praksisveiledere og lærere i et nytt, fleksibelt utdanningsforløp i fysioterapi
(Research report; Forskningsrapport, 2006)Denne rapporten er basert på er et aksjonsrettet prosjekt som har involvert et (ut)forskende partnerskap mellom tre studenter, fem praksisveiledere og to lærere. Vi har hatt studentenes læring i fokus og fulgt ulike læringsaktiviteter på ulike læringsarenaer over en periode på 5 mnd. Det har vært lærerikt for oss alle. Vi har reflektert over studenters læring og gjennom det: over vår egen ... -
Regional differences in renal replacement therapy in northern Norway 2000-2012
(Journal article; Tidsskriftartikkel, 2015-02-10)Objectives: Distance from residence location to a centre for renal replacement therapy (RRT) may influence patients’ quality of life and prognosis. Northern Norway constitutes 45% of Norway’s landmass, but has less than 10% of the population. <p>Methods: In this study, we analysed all patients in northern Norway consecutively registered in the Norwegian Renal Registry during 20002012. A total ... -
Regular physical activity and risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-05)Venous thromboembolism (VTE) is a complex multifactorial disease that represents a growing public health concern. Identification of modifiable risk factors at the population level may provide a measure to reduce the burden of VTE. In this review, we summarize current knowledge of the role of physical activity on the risk of VTE and VTE-related complications. We also discuss methodological challenges ... -
Regulation of TFPIα expression by miR-27a/b-3p in human endothelial cells under normal conditions and in response to androgens
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-27)The increased risk of cardiovascular events in older men is multifactorial, but the significant reduction of testosterone levels has been involved. As this hormone regulates the expression of TFPI by unknown mechanisms, we aimed to evaluate the role of miRNAs in the regulation of TFPIα expression under normal conditions and in response to androgens. In silico studies allowed the selection of 4 miRNAs ... -
Rehabilitation Needs, Service Provision, and Costs in the First Year Following Traumatic Injuries: Protocol for a Prospective Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-14)Background: Traumatic injuries, defined as physical injuries with sudden onset, are a major public health problem worldwide. There is a paucity of knowledge regarding rehabilitation needs and service provision for patients with moderate and major trauma, even if rehabilitation research on a spectrum of specific injuries is available.<p> <p>Objective: This study aims to describe the prevalence of ...
