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Loneliness in adolescence and prescription of psychotropic drugs in adulthood: 23-year longitudinal population-based and registry study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-11)Aims We aim to determine whether (a) experiencing loneliness in adolescence and (b) changes in loneliness from adolescence to adulthood are prospectively associated with prescriptions for a variety of psychotropic drugs in adulthood.<p> <p>Method We used data from a Norwegian population-based sample with 2602 participants, collected across four waves between 1992 and 2006. Loneliness was assessed ... -
Team-based learning (TBL) in clinical disciplines for undergraduate medical students—a scoping review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-03)Background Team-based learning (TBL) is an evidence-based pedagogical method that has been used in undergraduate medical education since 2001. However, its use in clinical disciplines is rarely reported, and the impact of its implementation is not known. The aim of this study was to explore and map the published literature on the impact of implementing TBL in clinical disciplines in undergraduate ... -
Disruption of sleep by one night of in-home polysomnographic recording: a longitudinal actigraphy study of patients with chronic musculoskeletal pain and pain-free controls
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-25)Background Patients with chronic pain frequently have comorbid sleep disturbances. Since improvement of sleep may alleviate both sleep problems and to some extent pain, sleep studies in this group becomes relevant. Polysomnography (PSG) is considered the gold standard for characterizing sleep; however, it is resource-demanding and may itself disrupt sleep due to the use of inconvenient equipment in ... -
Long-term cardiac effects of modern treatment for Hodgkin’s lymphoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-04)Background Hodgkin’s lymphoma (HL) is a hematological malignancy that affects both children and young adults. Traditional treatment is associated with a life-time prevalence of cardiac disease exceeding 50%. In the late 1990s protocols were modified to reduce cancer therapy-related adverse cardiac effects. This study aimed to assess the long-term impact of advances in treatment protocols on the ... -
Quality of life endpoints in cancer cachexia clinical trials: Systematic review 3 of the cachexia endpoints series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-29)The use of patient-reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self-report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. This review describes the frequency, variety, and reporting of QOL endpoints used in cancer cachexia clinical trials. Electronic literature searches were performed in Medline, ... -
A human stomach cell type transcriptome atlas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-14)Background The identification of cell type-specific genes and their modification under different conditions is central to our understanding of human health and disease. The stomach, a hollow organ in the upper gastrointestinal tract, provides an acidic environment that contributes to microbial defence and facilitates the activity of secreted digestive enzymes to process food and nutrients into ... -
Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity
(Journal article; Tidsskriftartikkel, 2024-02-08)<p><i>Background</i> Interactions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link between disease-specific gut microbiota alterations and circulating metabolites is lacking. <p><i>Methods</i> We performed shot-gun sequencing on 235 samples from 166 HF patients and 69 healthy control samples. Separate plasma samples from ... -
Machine Learning Models for Predicting Disability and Pain Following Lumbar Disc Herniation Surgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-07)IMPORTANCE Lumber disc herniation surgery can reduce pain and disability. However, a sizable minority of individuals experience minimal benefit, necessitating the development of accurate prediction models.<p> <p>OBJECTIVE To develop and validate prediction models for disability and pain 12 months after lumbar disc herniation surgery. <p>DESIGN, SETTING, AND PARTICIPANTS A prospective, multicenter, ... -
Thrombolytic Treatment in Wake-Up Stroke: A Propensity Score-Matched Analysis of Treatment Effectiveness in the Norwegian Stroke Registry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-31)BACKGROUND: Previous clinical trials found improved outcome of thrombolytic treatment in patients with ischemic wake-up stroke (WUS) selected by advanced imaging techniques. The authors assessed the effectiveness of thrombolytic treatment in patients with WUS in a nationwide stroke registry.<p> <p>METHODS AND RESULTS: Using propensity score matching, the authors assessed the effectiveness and ... -
Body mass index is associated with health-related quality of life and disease characteristics in young adults with juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-02)Background There is a growing interest concerning the relationship between obesity and several medical conditions and inflammation. Nevertheless, there is a lack of studies regarding body mass index (BMI) among patients with juvenile idiopathic arthritis (JIA). Our aim was to investigate the impact of BMI on health-related quality of life (HRQoL) measured with a 36-Item Short Form Survey (SF-36), ... -
Inadequate nutritional care for malnourished patients in four university hospitals – The QuaNuT study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-30)Background & Aims: Adequate nutritional care to malnourished patients is described as a human right, and recommendations from nutritional care guidelines are legally binding in Norway. The primary objective of this study was to investigate nutritional care in malnourished hospitalized patients. We also wanted to describe the association between malnutrition and length of stay (LOS), readmission, ... -
Generative artificial intelligence to produce high-fidelity blastocyst-stage embryo images
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-10)STUDY QUESTION - Can generative artificial intelligence (AI) models produce high-fidelity images of human blastocysts?<p> <p>SUMMARY ANSWER - Generative AI models exhibit the capability to generate high-fidelity human blastocyst images, thereby providing substantial training datasets crucial for the development of robust AI models.<p> <p>WHAT IS KNOWN ALREADY - The integration of AI into IVF ... -
Randomized controlled trial of nasogastric tube use after esophagectomy: Study protocol for the kinetic trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-16)Esophagectomy is a complex and complication laden procedure. Despite centralization, variations in perioparative strategies reflect a paucity of evidence regarding optimal routines. The use of nasogastric (NG) tubes post esophagectomy is typically associated with significant discomfort for the patients. We hypothesize that immediate postoperative removal of the NG tube is non-inferior to current ... -
Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-13)Loss-of-function mutation of ABCC9, the gene encoding the SUR2 subunit of ATP sensitive-potassium (KATP) channels, was recently associated with autosomal recessive ABCC9-related intellectual disability and myopathy syndrome (AIMS). Here we identify nine additional subjects, from seven unrelated families, harbouring different homozygous loss-of-function variants in ABCC9 and presenting with a conserved ... -
Needs for community-based rehabilitation services and support 12 months after moderate and severe physical traumatic injuries: a brief report
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08)Patients with physical traumatic injuries frequently require long-term rehabilitation services. To strengthen rehabilitation services in the postacute phase, we need to assess characteristics of this population and their healthcare and rehabilitation needs in the community. This brief report summarizes the frequency of unmet rehabilitation needs in community-based rehabilitation during the first ... -
The outcomes of team-based learning versus small group interactive learning in the obstetrics and gynecology course for undergraduate students
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-17)Introduction - Team-based learning (TBL) is a well-established active teaching method which has been shown to have pedagogical advantages in some areas such as business education and preclinical disciplines in undergraduate medical education. Increasingly, it has been adapted to clinical disciplines. However, its superiority over conventional learning methods used in clinical years of medical school ... -
Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-27)Background: Patients with ischemic stroke have increased risk of venous thromboembolism (VTE). Obesity is prevalent in stroke patients and a well-established risk factor for VTE. Whether obesity further increases the VTE risk in patients with stroke remains unclear.<p> <p>Objectives: We investigated the joint effect of ischemic stroke and obesity on the risk of incident VTE in a population-based ... -
Major depression mistaken as frontotemporal dementia due to PET scan
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-04-02)Frontotemporal dementia (FTD) is associated with progressive degeneration of the frontal lobes and this leads to changes in language, motor symptoms, behavior and executive functions.1 In an early stage, patients with FTD usually have intact memory functions.2 40% of the cases of FTD are misdiagnosed,3 with delayed diagnosis compared to other dementias.4 Differentiating FTD from other psychiatric ... -
Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-11)There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when compar ing interventions and their clinical value. The aim of this systematic review was to summarize and evaluate endpoints used to assess appetite and dietary intake in cancer cachexia clinical trials. A search for studies published from 1 January 1990 until 2 June 2021 was conducted ... -
Exploring the dynamics of situational interest in team-based learning in undergraduate medical education
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-07-30)Background Team-based learning (TBL) is a widely recognized instructional approach in medical education blending direct instruction with active-cooperative learning in small groups. While TBL is known to enhance knowledge acquisition, its impact on student motivation, particularly through situational interest, remains underexplored. This study aimed to investigate the development of situational ...
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