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dc.contributor.authorJacobsen, Bjarne Koster
dc.contributor.authorJaceldo-Siegl, Karen
dc.contributor.authorKnutsen, Synnøve Fønnebø
dc.contributor.authorFan, Jing
dc.contributor.authorOda, Keiji
dc.contributor.authorFraser, Gary E.
dc.date.accessioned2014-05-23T09:00:36Z
dc.date.available2014-05-23T09:00:36Z
dc.date.issued2014
dc.description.abstractObjectives: As little is known about the possible relationship between the intake of phytoestrogens and female fertility, we investigated the relationship between soy isoflavone intake and the risk of nulliparity and nulligravidity. Methods: A cross-sectional study of 11,688 North American Adventist women aged 30–50 years old with data regarding childbearing. These women were, as a group, characterized by a high proportion (54%) of vegetarians and a healthy lifestyle with a very low prevalence of smoking and alcohol use. Results: The mean isoflavone intake (17.9 mg per day) was very high compared to other Western populations. Only 6% of the women indicated no intake of isoflavones. We found, after adjustment for age, marital status, and educational level, an inverse relationship (P=0.05) between isoflavone intake and the likelihood of ever having become a mother. In women with high ($40 mg/day) isoflavone intake (12% of this group of women), the adjusted lifetime probability of giving birth to a live child was reduced by approximately 3% (95% CI: 0, 7) compared to women with low (,10 mg/day) intake. No relationships were found between the isoflavone intake and parity or age at first delivery in parous women. A similar inverse relationship (P=0.03) was found between the isoflavone intake and the risk of nulligravidity with a 13% (95% CI: 2, 26) higher risk of never have been pregnant in women with high ($40 mg/day) isoflavone intake. These relationships were found mainly in women who reported problems becoming pregnant. Conclusion: The findings suggest that a high dietary isoflavone intake may have significant impact on fertility.en
dc.identifier.citationInternational Journal of Women's Health 6(2014) s. 377-384en
dc.identifier.cristinIDFRIDAID 1127868
dc.identifier.doihttp://dx.doi.org/10.2147/IJWH.S57137
dc.identifier.issn1179-1411
dc.identifier.urihttps://hdl.handle.net/10037/6321
dc.identifier.urnURN:NBN:no-uit_munin_5894
dc.language.isoengen
dc.publisherDovePressen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en
dc.titleSoy isoflavone intake and the likelihood of ever becoming a mother: the Adventist Health Study-2en
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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