English
norskPostoperative insulin resistance and the metabolic and cellular responses to single-dose preoperative oral carbohydrate supplementation – Experimental studies in pigs
Permanent link
https://hdl.handle.net/10037/6455
Date
2014-06-17Type
Doctoral thesisDoktorgradsavhandling
Abstract
Gjennom en serie eksperimentelle studier på gris, inkludert etablering av en målemetode for utvikling av akutt insulinresistens, ble endringer i insulinsensitivitet og i lever- og skjelettmuskelceller undersøkt etter et stort kirurgisk inngrep. Resultatene viser at de cellulære endringene som ledsager utvikling av insulinresistens etter kirurgi har mange likhetstrekk med de endringer man ser ved type 2 diabetes. Et viktig funn i studien er at disse endringene til dels kan motvirkes ved å unngå faste og isteden innta en enkelt dose karbohydratdrikk like før kirurgi. Dette dempet en kirurgiutløst økning av betennelses-assosierte proteiner i muskelcellene og bedret den dempende effekten av insulin på produksjonen av et protein i muskulaturen som hemmer sukkeropptaket i mitokondrier. Funnene kan bidra til utvikling av nye kliniske strategier for ernæring før og etter kirurgiske inngrep.
Description
The papers of this thesis are not available in Munin:
1. Gjessing PF, Fuskevåg OM, Hagve M, Revhaug A, Irtun Ø.: 'Hyperinsulinemiceuglycemic step clamping with tracer glucose infusion and labeled glucose infusate for assessment of acute insulin resistance in pigs', AJP - Endocrinology and Metabolism (2010), vol .298, no. E1305-1312. Available at http://dx.doi.org/10.1152/ajpendo.00701.2009
2. Gjessing PF, Hagve M, Fuskevåg OM, Revhaug A, Irtun Ø.: 'Single-dose preoperative carbohydrate treatment in the immediate preoperative phase diminishes development of postoperative peripheral insulin resistance', Clinical Nutrition (2014), online before print. Available at http://dx.doi.org/10.1016/j.clnu.2014.02.010
3. Gjessing PF, Constantin-Teodosiu D, Hagve M, Lobo DN, Revhaug A, Irtun Ø.: 'Preoperative CHO supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression' (manuscript).
4. Hagve M, Gjessing PF, Fuskevåg OM, Revhaug A, Larsen TS, Irtun Ø.: 'Skeletal muscle mitochondria exhibit decreased pyruvate oxidation capacity and increased ROS release during surgery-induced acute insulin resistance' (manuscript).
1. Gjessing PF, Fuskevåg OM, Hagve M, Revhaug A, Irtun Ø.: 'Hyperinsulinemiceuglycemic step clamping with tracer glucose infusion and labeled glucose infusate for assessment of acute insulin resistance in pigs', AJP - Endocrinology and Metabolism (2010), vol .298, no. E1305-1312. Available at http://dx.doi.org/10.1152/ajpendo.00701.2009
2. Gjessing PF, Hagve M, Fuskevåg OM, Revhaug A, Irtun Ø.: 'Single-dose preoperative carbohydrate treatment in the immediate preoperative phase diminishes development of postoperative peripheral insulin resistance', Clinical Nutrition (2014), online before print. Available at http://dx.doi.org/10.1016/j.clnu.2014.02.010
3. Gjessing PF, Constantin-Teodosiu D, Hagve M, Lobo DN, Revhaug A, Irtun Ø.: 'Preoperative CHO supplementation attenuates post-surgery insulin resistance via reduced inflammatory inhibition of the insulin-mediated restraint on muscle pyruvate dehydrogenase kinase 4 expression' (manuscript).
4. Hagve M, Gjessing PF, Fuskevåg OM, Revhaug A, Larsen TS, Irtun Ø.: 'Skeletal muscle mitochondria exhibit decreased pyruvate oxidation capacity and increased ROS release during surgery-induced acute insulin resistance' (manuscript).
Publisher
UiT The Arctic University of NorwayUiT Norges arktiske universitet
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