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dc.contributor.authorSteigen, Sonja Eriksson
dc.contributor.authorHolm, Niels R.
dc.contributor.authorButt, Noreen
dc.contributor.authorMaeng, Michael
dc.contributor.authorOtsuka, Fumiyuki
dc.contributor.authorVirmani, Renu
dc.contributor.authorLadich, Elena
dc.contributor.authorSteigen, Terje
dc.date.accessioned2014-08-12T11:03:45Z
dc.date.available2014-08-12T11:03:45Z
dc.date.issued2014
dc.description.abstractObjectives. Patients previously treated with coronary stents may suffer an acute coronary syndrome (ACS) without any evidence of thrombus formation on coronary angiography (CAG). This may be due to partial, nonocclusive stent thrombosis with microembolization. In this paper, we illustrate possible mechanisms both with optical coherence tomography (OCT) and histology. Design. We present two cases with ACS from very late stent thrombosis who have been previously treated with fi rst-generation drug-eluting stents (DES). Results. The fi rst patient had ACS 15 months after DES implantation. The angiogram (CAG) was near normal with slight peri-stent contrast staining. OCT revealed abnormalities including thrombus not visible on CAG. These are fi ndings that may explain the ACS. The second patient had subclinical episodes with chest pain after DES implantation. The patient died from stent thrombosis in a DES. Postmortem histological examination of the coronary arteries revealed stent struts with little or no neointimal coverage, persistent peri-strut fi brin deposition, infl ammatory cells, malapposition, and small luminal platelet-rich thrombi. Old spotty myocardial infarctions were found in the supplied territory possibly caused by earlier episodes of embolizing thrombus. Conclusions. In patients with previous implanted DES presenting with ACS, OCT may detect abnormalities and thrombus formation not visible on CAG. Such fi ndings may impact the treatment strategy in these patients.en
dc.identifier.citationScandinavian Cardiovascular Journal 48(2014) s. 156-160en
dc.identifier.cristinIDFRIDAID 1145828
dc.identifier.doihttp://dx.doi.org/10.3109/14017431.2014.900185
dc.identifier.issn1401-7431
dc.identifier.urihttps://hdl.handle.net/10037/6519
dc.identifier.urnURN:NBN:no-uit_munin_6122
dc.language.isoengen
dc.publisherInforma healthcareen
dc.rights.accessRightsopenAccess
dc.subjectAngiografien
dc.subjectTromboseen
dc.subjectOptisk koherens tomografien
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en
dc.titleClincal use of optical coherence tomography to identify angiographic silent stent thrombosisen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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