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dc.contributor.advisorMollnes, Tom Eirik
dc.contributor.authorSkjeflo, Espen Waage
dc.date.accessioned2014-09-17T10:45:06Z
dc.date.available2014-09-17T10:45:06Z
dc.date.issued2014-05-30
dc.description.abstractSepsis is an old and lethal disease caused by immune dysfunction in response to infection. The innate immune system is the first responder to infection and the first to dysfunction. It comprises both humoral and cellular components such as the complement, coagulation and fibrinolytic cascade systems as well as the polymorphonuclear neutrophils and monocytes. These usually recognize and respond to pathogens in an orderly fashion, leading to resolution of infection and restored homeostasis. However, in sepsis the response is first exaggerated and later reduced or even non-existent. As of today, patients suffering from sepsis only receive antibiotic and supportive treatment. The Gram-positive bacterium Staphylococcus aureus is a frequent cause of infection and sepsis. It is well known for its wide antibiotic resistance and ability to survive within humans. Several membrane-bound and secreted proteins promote staphylococcal infection by inactivating complement, surviving within phagocytes and exploiting coagulation to disseminate with the host. However, an overview of the mechanisms and virulence factors involved is currently not found. This review therefore covers documented interactions between S. aureus and the complement system, the coagulation and fibrinolytic systems as well as neutrophils and monocytes in infection and sepsis following a brief introduction to each topic. The aim is to give both the reader and the writer an overview of the current knowledge and ongoing research.en
dc.identifier.urihttps://hdl.handle.net/10037/6682
dc.identifier.urnURN:NBN:no-uit_munin_6282
dc.language.isoengen
dc.publisherUiT Norges arktiske universiteten
dc.publisherUiT The Arctic University of Norwayen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2014 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDMED-3950en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi: 715en
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en
dc.titleStaphylococcus aureus and innate immunityen
dc.typeMaster thesisen
dc.typeMastergradsoppgaveen


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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)