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dc.contributor.authorEvjenth, Bjørg
dc.contributor.authorHansen, Tonje Elisabeth
dc.contributor.authorBrekke, Ole Lars
dc.contributor.authorHolt, Jan
dc.date.accessioned2015-08-04T12:20:24Z
dc.date.available2015-08-04T12:20:24Z
dc.date.issued2014-03-31
dc.description.abstractAim: Paediatric cut-off values for serum allergen-specific IgE (sIgE) using the Siemens IMMULITE 2000 system to diagnose allergic rhinoconjunctivitis have not been established. We aimed to determine cut-off levels for sIgE for 10 common inhalant allergens and to study the relationship between sIgE, total IgE and fractional exhaled nitric oxide (FENO). <br>Methods: We enrolled 243 schoolchildren, including 164 with allergic rhinoconjunctivitis. Parental interviews, skin prick tests, sIgE, total IgE, FENO measurements, spirometry and exercise tests were performed. <br>Results: Cut-off values with the best combined sensitivity and specificity were above the detection limit of the assay for seven of the ten allergens (0.23–1.1 kU/L). The overall accuracy of the IMMULITE in detecting allergic rhinoconjunctivitis was good. sIgE was superior to total IgE and FENO in predicting allergic rhinoconjunctivitis to timothy, birch, mugwort, cat, dog and house dust mite. FENO was elevated in children with allergic rhinoconjunctivitis, irrespective of asthma. <br>Conclusion: Cut-off values for sIgE were dependent on the allergic phenotype and were above the IMMULITE detection limit for seven of ten inhalant allergens. Consequently, using the detection limit for sIgE as the decision point would result in over-diagnosing allergic rhinoconjunctivitis. When measuring elevated FENO in children, allergic rhinoconjunctivitis should be suspected.en_US
dc.identifier.citationActa Paediatrica 103(2014) nr. 7 s. 759-765en_US
dc.identifier.cristinIDFRIDAID 1159316
dc.identifier.doi10.1111/apa.12631
dc.identifier.issn0803-5253
dc.identifier.urihttps://hdl.handle.net/10037/7900
dc.identifier.urnURN:NBN:no-uit_munin_7468
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Pediatri: 760en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Pediatrics: 760en_US
dc.subjectAllergic rhinoconjunctivitisen_US
dc.subjectChildrenen_US
dc.subjectExhaled nitric oxideen_US
dc.subjectSkin prick testen_US
dc.subjectSpecific IgEen_US
dc.titleEstablishing IMMULITE® 2000 cut-off values for serum allergen-specific immunoglobulin and exploring their relationship to exhaled nitric oxideen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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