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dc.contributor.authorVårtun, Åse
dc.contributor.authorFlo, Kari
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorAcharya, Ganesh
dc.date.accessioned2015-09-14T07:16:31Z
dc.date.available2015-09-14T07:16:31Z
dc.date.issued2015-08-10
dc.description.abstractObjective: Cardiovascular response to passive leg raising (PLR) is useful in assessing preload reserve, but it has not been studied longitudinally during pregnancy. We aimed to investigate gestational age associated serial changes in maternal functional hemodynamics and establish longitudinal reference ranges for the second half of pregnancy. Materials and Methods: This was a prospective longitudinal study on 98 healthy pregnant women who were examined 3–5 times during 20–40 weeks of gestation (a total of 441 observations). Maternal cardiac function and systemic hemodynamics were assessed at baseline and 90 seconds after PLR using impedance cardiography (ICG). The main outcome measures were gestational age specific changes in ICG-derived variables of maternal cardiovascular function and functional hemodynamic response to PLR. Results: Hemodynamic response to PLR varied during pregnancy. PLR led to an insignificant increase in stroke volume during 20+0 to 31+6 weeks, but later in gestation the stroke volume was slightly lower at PLR compared to baseline. PLR caused no significant change in cardiac output between 20+0 and 23+6 weeks and a significant decrease after 24+0 weeks. A decrease in heart rate, mean arterial pressure, and cardiac contractility was observed during PLR throughout the second half of pregnancy. Systemic vascular resistance was reduced by PLR up to 32+0 weeks, but increased slightly thereafter. Conclusion: Healthy pregnant women appear to have limited preload reserve and reduced cardiac contractility, especially in the third trimester, which makes them vulnerable to fluid overload and cardiac failure.en_US
dc.description.sponsorshipThis study was funded by the Regional Health Authority of Northern Norway (Helse-Nord), Grant No. SFP873/ID1646, GA.en_US
dc.identifier.citationPLoS ONE 10(8): e0135300 (2015)en_US
dc.identifier.cristinIDFRIDAID 1259772
dc.identifier.doi10.1371/journal.pone.0135300
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/8051
dc.identifier.urnURN:NBN:no-uit_munin_7640
dc.language.isoengen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.rights.accessRightsopenAccess
dc.subjectpregnancyen_US
dc.subjectLongitudinal Studyen_US
dc.subjectMaternal Functional Hemodynamicsen_US
dc.subjectcardiovascular responseen_US
dc.subjecthemodynamic responseen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756en_US
dc.titleMaternal functional hemodynamics in the second half of pregnancy: A longitudinal studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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