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dc.contributor.advisorSveinbjørnsson, Baldur
dc.contributor.advisorCamilio, Ketil André
dc.contributor.authorMauseth, Brynjar
dc.date.accessioned2015-07-08T05:12:05Zen_US
dc.date.accessioned2016-02-05T13:24:03Z
dc.date.available2016-02-05T13:24:03Z
dc.date.issued2015-05-11
dc.description.abstractAntimicrobial peptides are part of the innate immune defence of many organisms and represent a novel class of therapeutics due to their broad-spectrum activities, including cytotoxic activity against cancer cells. It has recently been reported that small antimicrobial β2,2-amino acid derivatives (Mw<500), such as LTX-401, possess potent anticancer activity against Ramos human Burkitt’s lymphoma cells. In the present thesis, the anticancer properties displayed by LTX-401 became subject for a continued investigation. In vitro cytotoxicity studies revealed that LTX-401 was highly active against a panel of malignant cells including murine and human cancer cell lines. Moreover, LTX-401 was found to induce known features of immunogenic cell death as shown by the release of Damage-Associated Molecular Pattern molecules such as High-Mobility Group Box-1 protein, adenosine triphosphate and cytochrome c in vitro. Intralesional administration of LTX-401 into intradermally established B16 melanomas in syngeneic mice resulted in complete regression of the tumor. Moreover, cured animals that were given a second tumor challenge with live B16F1 cells did not develop tumor and displayed immune protection against the cancer. Altogether, these results underscore the therapeutic potential of LTX-401 in conveying local tumor control and generation of protective immunity, presumably by the engagement of immunogenic cell death.en_US
dc.identifier.urihttps://hdl.handle.net/10037/8436
dc.identifier.urnURN:NBN:no-uit_munin_8006
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2015 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDMBI-3911en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en_US
dc.titleOncolytic Activity and Mechanisms of Action by a small β2,2-amino acid derivative LTX-401en_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
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