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dc.contributor.authorKilvær, Thomas Karsten
dc.contributor.authorRakaeekhanehkenari, Mehrdad
dc.contributor.authorHellevik, Turid
dc.contributor.authorAl-Saad, Samer
dc.contributor.authorPaulsen, Erna-Elise
dc.contributor.authorBusund, Lill-Tove
dc.contributor.authorDønnem, Tom
dc.contributor.authorMartinez, Inigo Zubiavrre
dc.date.accessioned2016-03-04T11:49:00Z
dc.date.available2016-03-04T11:49:00Z
dc.date.issued2015-08-07
dc.description.abstractBackground Cancer Associated Fibroblasts (CAFs) are thought to regulate tumor growth and metastasis. Fibroblast Activating Protein 1 (FAP-1) is a marker for fibroblast activation and by many recognized as the main marker of CAFs. Alpha Smooth Muscle Actin (α-SMA) is a general myofibroblast marker, and can be used to identify CAFs. This study investigates the prognostic impact of FAP-1 and α-SMA in non-small cell lung cancer (NSCLC) patients and correlates their expression to 105 proteins investigated in the same cohort. <p>Methods Tumor specimens from 536 NSCLC patients were obtained and tissue micro-arrays were constructed. Immunohistochemistry was used to evaluate the expression of FAP-1 and α- SMA and explore their impact on survival and association with other tumor molecular markers in NSCLC patients. <p>Results High expression of FAP-1, but not α-SMA, in squamous cell carcinoma (SCC, P = 0.043, HR = 0.63 95% CI 0.40–0.99) was significantly associated with increased disease-specific survival. FAP-1 and α-SMA were not significantly correlated to each other. Analyses of FAP-1 and α-SMA associated with other tumor-related proteins revealed histotype-specific correlation patterns. <p>Conclusion The presence of FAP-1 expressing CAFs is an indicator of positive outcome for NSCLCSCC patients. In addition, correlation analyses suggest FAP-1 and α-SMA to label different subsets of fibroblasts and their associations with other tumor-related proteins diverge according to histological subtype.en_US
dc.identifier.citationPLoS ONE 2015, 10:e0134965(8)en_US
dc.identifier.cristinIDFRIDAID 1286072
dc.identifier.doi10.1371/journal.pone.0134965
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/8691
dc.identifier.urnURN:NBN:no-uit_munin_8263
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762en_US
dc.titleCancer associated fibroblasts in stage I-IIIA NSCLC: Prognostic impact and their correlations with tumor molecular markersen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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