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dc.contributor.authorFasanelli, Francesca
dc.contributor.authorBaglietto, Laura
dc.contributor.authorPonzi, Erica
dc.contributor.authorGuida, Florence
dc.contributor.authorCampanella, Gianluca
dc.contributor.authorJohansson, Mattias
dc.contributor.authorGrankvist, Kjell
dc.contributor.authorJohansson, Mikael
dc.contributor.authorAssumma, Manuela Bianca
dc.contributor.authorNaccarati, Alessio
dc.contributor.authorChadeau-Hyam, Marc
dc.contributor.authorAla, Ugo
dc.contributor.authorFaltus, Christian
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorRisch, Angela
dc.contributor.authorDe Stavola, Bianca
dc.contributor.authorHodge, Allison
dc.contributor.authorGiles, Graham G.
dc.contributor.authorSouthey, Melissa C.
dc.contributor.authorRelton, Caroline L.
dc.contributor.authorHaycock, Philip C.
dc.contributor.authorLund, Eiliv
dc.contributor.authorPolidoro, Silvia
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorVineis, Paolo
dc.date.accessioned2016-03-09T08:24:54Z
dc.date.available2016-03-09T08:24:54Z
dc.date.issued2015-12-15
dc.description.abstractDNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case–control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, 95% CI: 0.31–0.54, P-value=3.3 × 10−11) and cg03636183 in F2RL3 (OR for 1 s.d.=0.40, 95% CI: 0.31–0.56, P-value=3.9 × 10−10), previously shown to be strongly hypomethylated in smokers. These associations remain significant after adjustment for smoking and are confirmed in additional 664 case–control pairs tightly matched for smoking from the MCCS, NSHDS and EPIC HD cohorts. The replication and mediation analyses suggest that residual confounding is unlikely to explain the observed associations and that hypomethylation of these CpG sites may mediate the effect of tobacco on lung cancer risk.en_US
dc.descriptionPublished version. Source at <a href=http://doi.org/10.1038/ncomms10192>http://doi.org/10.1038/ncomms10192</a>.en_US
dc.identifier.citationNature Communications 2015, 6:10192en_US
dc.identifier.cristinIDFRIDAID 1331098
dc.identifier.doi10.1038/ncomms10192
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/10037/8785
dc.identifier.urnURN:NBN:no-uit_munin_8382
dc.language.isoengen_US
dc.publisherNatureen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.titleHypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohortsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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