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dc.contributor.authorRomaguera, Dora
dc.contributor.authorWard, Heather
dc.contributor.authorWark, Petra A.
dc.contributor.authorVergnaud, Anne-Claire
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorvan Gils, Carla H.
dc.contributor.authorFerrari, Pietro
dc.contributor.authorFedirko, Veronika
dc.contributor.authorJenab, Mazda
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorDossus, Laure
dc.contributor.authorDartois, Laureen
dc.contributor.authorHansen, Camilla Plambeck
dc.contributor.authorDahm, Christina Catherine
dc.contributor.authorBuckland, Genevieve
dc.contributor.authorSánchez, María-José
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorNavarro, Carmen
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorKey, Timothy J.
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorTsironis, Christos
dc.contributor.authorLagiou, Pagona
dc.contributor.authorMasala, Giovanna
dc.contributor.authorPala, Valeria
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno-de-Mesquita, H. Bas
dc.contributor.authorSiersema, Peter D.
dc.contributor.authorOhlsson, Bodil
dc.contributor.authorJirström, Karin
dc.contributor.authorWennberg, Maria
dc.contributor.authorNilsson, Lena Maria
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorKühn, Tilman
dc.contributor.authorKatzke, Verena A.
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBoeing, Heiner
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorGunter, Mark J.
dc.contributor.authorRiboli, Eilo
dc.contributor.authorNorat, Teresa
dc.date.accessioned2016-03-10T10:56:20Z
dc.date.available2016-03-10T10:56:20Z
dc.date.issued2015-05-07
dc.description.abstractBackground: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients. <p>Methods: The association between the WCRF/AICR score (score range 0–6 in men and 0–7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality. <p>Results: The HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/ women: 2.25–2.75/3.25–3.75), third (3–3.75/4–4.75), and fourth (4–6/5–7) categories of the score were 0.87 (0.72–1.06), 0.74 (0.61–0.90), and 0.70 (0.56–0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0–2/0–3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models. <p>Conclusions: Greater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.en_US
dc.descriptionPublished version, also available at <a href=http://dx.doi.org/10.1186/s12916-015-0332-5>http://dx.doi.org/10.1186/s12916-015-0332-5</a>en_US
dc.identifier.citationBMC Medicine (2015) 13:107en_US
dc.identifier.cristinIDFRIDAID 1256297
dc.identifier.doi10.1186/s12916-015-0332-5
dc.identifier.issn1741-7015
dc.identifier.urihttps://hdl.handle.net/10037/8839
dc.identifier.urnURN:NBN:no-uit_munin_8420
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectColorectal canceren_US
dc.subjectDieten_US
dc.subjectHealthy lifestyleen_US
dc.subjectPhysical activityen_US
dc.subjectSurvivalen_US
dc.subjectWeighten_US
dc.titlePre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: A cohort studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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