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dc.contributor.authorVold, Monica Linea
dc.contributor.authorAasebø, Ulf
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorMelbye, Hasse
dc.date.accessioned2016-03-11T09:28:38Z
dc.date.available2016-03-11T09:28:38Z
dc.date.issued2015-02-12
dc.description.abstractBackground: Oxygen saturation has been shown in risk score models to predict mortality in emergency medicine. The aim of this study was to determine whether low oxygen saturation measured by a single-point measurement by pulse oximetry (SpO2) is associated with increased mortality in the general adult population. <p>Methods: Pulse oximetry was performed in 5,152 participants in a cross-sectional survey in Tromsø, Norway, in 2001–2002 (“Tromsø 5”). Ten-year follow-up data for all-cause mortality and cause of death were obtained from the National Population and the Cause of Death Registries, respectively. Cause of death was grouped into four categories: cardiovascular disease, cancer except lung cancer, pulmonary disease, and others. SpO2 categories were assessed as predictors for all-cause mortality and death using Cox proportional-hazards regression models after correcting for age, sex, smoking history, body mass index (BMI), C-reactive protein level, self-reported diseases, respiratory symptoms, and spirometry results. <p>Results: The mean age was 65.8 years, and 56% were women. During the follow-up, 1,046 (20.3%) participants died. The age- and sex-adjusted hazard ratios (HRs) (95% confidence intervals) for all-cause mortality were 1.99 (1.33–2.96) for SpO2 ≤ 92% and 1.36 (1.15–1.60) for SpO2 93–95%, compared with SpO2 ≥ 96%. In the multivariable Cox proportional-hazards regression models that included self-reported diseases, respiratory symptoms, smoking history, BMI, and CRP levels as the explanatory variables, SpO2 remained a significant predictor of all-cause mortality. However, after including forced expiratory volume in 1 s percent predicted (FEV1% predicted), this association was no longer significant. Mortality caused by pulmonary diseases was significantly associated with SpO2 even when FEV1% predicted was included in the model. <p>Conclusions: Low oxygen saturation was independently associated with increased all-cause mortality and mortality caused by pulmonary diseases. When FEV1% predicted was included in the analysis, the strength of the association weakened but was still statistically significant for mortality caused by pulmonary diseases.en_US
dc.descriptionPublished version, also available at <a href=http://dx.doi.org/10.1186/s12890-015-0003-5>http://dx.doi.org/10.1186/s12890-015-0003-5</a>en_US
dc.identifier.citationBMC Pulmonary Medicine (2015) 15:9en_US
dc.identifier.cristinIDFRIDAID 1237978
dc.identifier.doi10.1186/s12890-015-0003-5
dc.identifier.issn1471-2466
dc.identifier.urihttps://hdl.handle.net/10037/8876
dc.identifier.urnURN:NBN:no-uit_munin_8459
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Lungesykdommer: 777en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Lung diseases: 777en_US
dc.titleLow oxygen saturation and mortality in an adult cohort; the Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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