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dc.contributor.authorKaneva, Anastasiya M.
dc.contributor.authorPotolitsyna, Natalya N.
dc.contributor.authorBojko, Evgeny R.
dc.contributor.authorOdland, Jon Øyvind
dc.date.accessioned2016-03-14T10:30:46Z
dc.date.available2016-03-14T10:30:46Z
dc.date.issued2015
dc.description.abstractBackground. The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoAI-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting the presence or absence of cardiovascular disease, less is known about apoB/apoA-I ratio as a marker of plasma atherogenicity. Methods. A total of 157 normolipidemic men aged 20–59 years were included in the study. The plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apoA-I, apoB, and apoE were determined after a 12 h fasting period. Results. The median of the apoB/apoA-I ratio in the studied normolipidemic subjects was 0.52, with values ranging from 0.19 to 2.60. The percentage of subjects with the apoB/apoA-I ratio exceeding 0.9 (the accepted risk value of cardiovascular disease) was 19.1%. The subjects with apoB/apoA-I>0.9 were characterized by higher TG levels and atherogenic index of plasma (AIP) and lower values of ratio of low-density lipoprotein cholesterol (LDLC) to apoB (LDL-C/apoB) and apoE levels compared with men with apoB/apoA-I<0.9. Conclusion. Despite normolipidemia, the subjects with the unfavorable apoB/apoA-I ratio had more atherogenic lipid profile.en_US
dc.identifier.citationDisease Markers 2015, 2015:591454en_US
dc.identifier.cristinIDFRIDAID 1239843
dc.identifier.doi10.1155/2015/591454
dc.identifier.issn0278-0240
dc.identifier.urihttps://hdl.handle.net/10037/8919
dc.identifier.urnURN:NBN:no-uit_munin_8500
dc.language.isoengen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.titleThe Apolipoprotein B/Apolipoprotein A-I Ratio as a Potential Marker of Plasma Atherogenicityen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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