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dc.contributor.authorLiodden, Ingrid Elisabeth
dc.contributor.authorSandvik, Leiv
dc.contributor.authorValeberg, Berit Taraldsen
dc.contributor.authorBorud, Einar Kristian
dc.contributor.authorNorheim, Arne Johan
dc.date.accessioned2016-03-14T13:39:23Z
dc.date.available2016-03-14T13:39:23Z
dc.date.issued2015-04-13
dc.description.abstractObjectives. To investigate the effect of a standardised acupuncture on nausea and vomiting in children after tonsillectomy with or without adenoidectomy when possible placebo effects were precluded. Methods. A pragmatic, multicentre, double-blinded, randomised controlled trial. The study was conducted over 10 months in 2012–2013 at three ambulatory clinics. Two hundred and eighty-two children, age 1–11 years, American Society of Anesthesiologists grade ≤II, were included. To equalise expectancy effects, all parents were told that their child would receive acupuncture. However, children were randomly allocated to perioperative bilateral needling acupuncture at PC6, depth 7 mm, mean time 17 min (SD 5–45) during anaesthesia plus usual care, or to usual care only. The regional ethics committee approved this approach. Primary endpoints were nausea and vomiting 24 h postoperatively. Results. This study did not demonstrate any effect of acupuncture (95% CI) compared with standard care. The overall vomiting in the acupuncture and usual-care groups was 44.2% and 47.9%, respectively. Nausea was experienced by 31.7% in the acupuncture group and by 32.6% in the usual-care group. The test power was acceptable for comparisons of vomiting. Conclusions. The findings suggest that when controlling for possible placebo effects standardised PC6 acupuncture needling during anaesthesia without further stimulation of PC6 is not effective in reducing nausea and vomiting in children after tonsillectomy with or without adenoidectomy. Future studies should investigate acupuncture treatment which balances adequate dose and technique and a feasible, child-friendly acupuncture treatment. Trial registration number ClinicalTrials.gov NCT01729052.en_US
dc.descriptionAccepted manuscript version. Published version at <a href=http://doi.org/10.1136/acupmed-2014-010738>http://doi.org/10.1136/acupmed-2014-010738</a>.en_US
dc.identifier.citationAcupuncture in Medicine 2015:1-8en_US
dc.identifier.cristinIDFRIDAID 1237732
dc.identifier.doi10.1136/acupmed-2014-010738
dc.identifier.issn1759-9873
dc.identifier.urihttps://hdl.handle.net/10037/8936
dc.identifier.urnURN:NBN:no-uit_munin_8478
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.rights.accessRightsopenAccess
dc.subjectacupunctureen_US
dc.subjecttonsillectomy childrenen_US
dc.subjectpostoperative nausea and vomitingen_US
dc.subjectpostoperative painen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.titleAcupuncture versus usual care for postoperative nausea and vomiting in children after tonsillectomy/adenoidectomy: a pragmatic, multicenter, double-blinded, randomized trialen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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