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dc.contributor.authorBesada, Emilio
dc.date.accessioned2016-03-14T14:51:21Z
dc.date.available2016-03-14T14:51:21Z
dc.date.issued2016
dc.description.abstractBackground. 29 GPA patients from the Northern Norway vasculitis disease registry received rituximab (RTX) induction and maintenance. 24% and 31% had, respectively, severe and chronic infections while 45% had hypogammaglobulinemia and 28% discontinued RTX due to hypogammaglobulinemia. The aim of the study was to examine how known predictors and adverse events interacted with adverse events using structural statistical methods. Methods. Five predictors (age, cyclophosphamide, total Ig and CD4/CD8 ratio prior RTX, and type of RTX maintenance regimen) and 4 adverse events (severe and chronic infections, hypogammaglobulinemia, and RTX discontinuation) were modeled in principal component and redundancy analyses. Results. The 5 predictors explained 51% of the variance of the GPA cohort. Models including cyclophosphamide exposure and total Ig level predicted best adverse events. However total Ig level has low R squared. The 2 best combinations of adverse events explained 13% of the variance of the predictors and adverse events. Only chronic infections were associated with combination of all adverse events (P= 0.014). Hypogammaglobulinemia did not seem associated with the other adverse events. Conclusions. Traditional risk factors for infections and hypogammaglobulinemia seemed to poorly predict adverse events in our GPA cohort.en_US
dc.identifier.citationAutoimmune Diseases 2016, 2016: 8095695en_US
dc.identifier.cristinIDFRIDAID 1317022
dc.identifier.doi10.1155/2016/8095695
dc.identifier.issn2090-0430
dc.identifier.urihttps://hdl.handle.net/10037/8940
dc.identifier.urnURN:NBN:no-uit_munin_8481
dc.language.isoengen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.urihttp://dx.doi.org/10.1155/2016/8095695en_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759en_US
dc.subjectVDP::Midical sciences: 700::Clinical medical sciences: 750::Rheumatology: 759en_US
dc.titleRisk Factors and Adverse Events Poorly Predict Infections and Hypogammaglobulinemia in Granulomatosis with Polyangiitis Patients Receiving Rituximaben_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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