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Loss of interleukin 33 expression in colonic crypts- a potential marker for disease remission in ulcerative colitis

Permanent link
https://hdl.handle.net/10037/9868
DOI
https://doi.org/10.1038/srep35403
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Date
2016-10-17
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Gundersen, Mona Dixon; Goll, Rasmus; Hol, Johanna; Olsen, Trine; Rismo, Renathe; Sørbye, Sveinung Wergeland; Sundnes, Olav; Haraldsen, Guttorm; Florholmen, Jon
Abstract
Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer look at IL-33 expression in well-defined clinical stages of UC. A total of 50 study participants (29 UC patients and 21 healthy controls) were included from a prospective cohort of inflammatory bowel disease patients treated to disease remission with infliximab, a tumour necrosis factor alpha (TNF) inhibitor. To our knowledge this is the first study examining mucosal IL-33 expression before and after anti-TNF therapy. In colonic mucosal biopsies we found a 3-fold increase in IL-33 gene expression comparing acute UC to healthy controls (p < 0.01). A significant reduction of IL33 between acute UC and disease remission was observed when TNF normalised in the mucosa (p = 0.02). Immunostaining revealed IL-33 in the nuclei of epithelial cells of scattered colonic crypts in acute disease, while at disease remission, IL-33 was undetectable, a novel finding suggesting that enterocyte-derived IL-33 is induced and maintained by inflammatory mediators.
Is part of
Gundersen, M.D. (2022). Interleukin 33: a locally induced alarmin in the colonic mucosa of ulcerative colitis. (Doctoral thesis). https://hdl.handle.net/10037/26707
Publisher
Nature Publishing Group
Citation
Scientific Reports 2016, 6:35403
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