Blar i forfatter "Håheim, Brage"
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Accidental hypothermia - A review on the underlying physiological and pathophysiological mechanisms and treatment of accidental hypothermia
Håheim, Brage (Master thesis; Mastergradsoppgave, 2014-06-01)Accidental hypothermia is a rare condition with few deaths per year, but hypothermic patients have a 30% chance of dying. The past 15-20 years there has been an increased understanding of how hypothermia affects human physiology and may cause life-threatening conditions like arrhythmias, cardiovascular shock and pulmonary edema. New understanding of underlying mechanisms of hypothermia- induced ... -
Comparison between two pharmacologic strategies to alleviate rewarming shock: vasodilation vs. inodilation
Håheim, Brage; Kondratyev, Timofey; Dietrichs, Erik Sveberg; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-12)Rewarming from hypothermia is often challenged by coexisting cardiac dysfunction, depressed organ blood flow (OBF), and increased systemic vascular resistance. Previous research shows cardiovascular inotropic support and vasodilation during rewarming to elevate cardiac output (CO). The present study aims to compare the effects of inodilatation by levosimendan (LS) and vasodilation by nitroprusside ... -
Effects of rewarming with extracorporeal membrane oxygenation to restore oxygen transport and organ blood flow after hypothermic cardiac arrest in a porcine model
Nilsen, Jan Harald; Schanche, Torstein Lindahl; Valkov, Sergey; Mohyuddin, Rizwan; Håheim, Brage; Kondratyev, Timofey; Næsheim, Torvind; Sieck, Gary C.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)We recently documented that cardiopulmonary resuscitation (CPR) generates the same level of cardiac output (CO) and mean arterial pressure (MAP) during both normothermia (38 °C) and hypothermia (27 °C). Furthermore, continuous CPR at 27 °C provides O2 delivery (ḊO2) to support aerobic metabolism throughout a 3-h period. The aim of the present study was to investigate the effects of extracorporeal ... -
The hemodynamic aspects of pharmacological manipulation of cardiac contractility and vascular resistance in rewarming from hypothermia
Håheim, Brage (Doctoral thesis; Doktorgradsavhandling, 2018-12-07)<p><i>Paper I</i> <br>To describe hemodynamic response and phosphorylation of cardiac troponin I during rewarming from deep, stable hypothermia with use of the calcium sensitizer and PDE3 inhibitor levosimendan, compared to animals given placebo. <p> <p><i>Paper II</i> <br>To describe hemodynamic response to lowered systemic vascular resistance by nitroprusside administration during rewarming ...