Wedrén, Sara; Weiderpass, Elisabete; Lovmar, Lovisa; Humphreys, Keith; Magnusson, Cecilia; Melhus, Håkan; Syvänen, Ann-Christine; Kindmark, Andreas; Landegren, Ulf; Fermér, Maria Lagerström; Stiger, Fredrik; Persson, Ingemar; Baron, John A (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-11-06)
Background: Estrogen is an established endometrial carcinogen. One of the most important
mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether
polymorphic variation in the estrogen receptor alpha gene (ESR1) is associated with endometrial
cancer risk.
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Methods: In 702 cases with invasive endometrial cancer and 1563 controls, we genotyped five
markers ...