Background: Cefiderocol is a novel siderophore β-lactam with improved hydrolytic stability toward β-lactamases, including carbapenemases, achieved by combining structural moieties of two clinically efficient cephalosporins, ceftazidime and cefepime. Consequently, cefiderocol represents a treatment alternative for infections caused by MDR Gram-negatives.<p> <p>Objectives: To study the role of ...

Background: Techniques have been developed to compute statistics on distributed datasets without revealing private information except the statistical results. However, duplicate records in a distributed dataset may lead to incorrect statistical results. Therefore, to increase the accuracy of the statistical analysis of a distributed dataset, secure deduplication is an important preprocessing step.<p><p> ...

Svalbard is a remote and scarcely populated Arctic archipelago and is considered to be mostly influenced by long-range-transported air pollution. However, there are also local emission sources such as coal and diesel power plants, snowmobiles and ships, but their influence on the background concentrations of trace gases has not been thoroughly assessed. This study is based on data of tropospheric ...

Trust is generally considered to play a key enabling role in water governance. Despite this notion, there have been no systematic assessments examining the way in which the literature on water governance engages with ‘trust’. Our article fills this gap by providing an overview of the way in which this literature has engaged with trust as a conceptual lens, analytical device and empirical phenomenon. ...

Med utgangspunkt i personlige erfaringer og empiriske undersøkelser, tar jeg i denne oppgaven fatt på å gi et filosofisk svar på hvorfor naturopplevelsen ser ut til å stimulere til kreativitet. Jeg bruker spesifikke momenter fra Graham Harmans objektorienterte ontologi til å argumentere for at artefakter døyver opplevelser av verden som annen og fremmed fra vår egen 'livsverden', og dermed bidrar ...

Background: The development of COVID-19 vaccines has been crucial in fighting the pandemic. However, misinformation about the COVID-19 pandemic and vaccines is spread on social media platforms at a rate that has made the World Health Organization coin the phrase infodemic. False claims about adverse vaccine side effects, such as vaccines being the cause of autism, were already considered a threat ...

The botanical compound rotenone is extensively used to eradicate populations and reduce the negative impacts of freshwater invasive animals. The method is controversial as non-target organisms often are negatively affected, but these effects are highly variable among taxa and may be difficult to monitor on species-level as many invertebrates are challenging or costly to identify using morphology. ...

The innate immune system is rapidly activated during myocardial infarction and blockade of extracellular complement system reduces infarct size. Intracellular complement, however, appears to be closely linked to metabolic pathways and its role in ischemia-reperfusion injury is unknown and may be different from complement activation in the circulation. The purpose of the present study was to investigate ...

Background: Accidental hypothermia (AH) is an unintended decrease in body core temperature (BCT) to below 35°C. We present an update on physiological/pathophysiological changes associated with AH and rewarming from hypothermic cardiac arrest (HCA).<p> <p>Temperature Regulation and Metabolism: Triggered by falling skin temperature, Thyrotropin-Releasing Hormone (TRH) from hypothalamus induces ...

Novel species of fungi described in this study include those from various countries as follows: Australia, Agaricus albofoetidus, Agaricus aureoelephanti and Agaricus parviumbrus on soil, Fusarium ramsdenii from stem cankers of Araucaria cunninghamii, Keissleriella sporoboli from stem of Sporobolus natalensis, Leptosphaerulina queenslandica and Pestalotiopsis chiaroscuro from leaves of Sporobolus ...