Oncolytic peptides represent a novel, promising cancer treatment strategy with activity in a broad spectrum of cancer entities, including colorectal cancer (CRC). Cancer cells are killed by immunogenic cell death, causing long-lasting anticancer immune responses, a feature of particular interest in non-immunogenic CRC. Oncolytic peptides DTT-205 and DTT-304 were administered by intratumoral injection ...

The categories pCS(X,Pro(k)) of precosheaves and CS(X,Pro(k)) of cosheaves on a small Grothendieck site X, with values in the category Pro(k) of prok-modules, are constructed. It is proved that pCS(X,Pro(k)) satisfies the AB4 and AB5* axioms, while CS(X,Pro(k)) satisfies AB3 and AB5*. Homology theories for cosheaves and precosheaves, based on quasi-projective resolutions, are constructed and investigated.

Deception Island (South Shetland Islands) is one of the most active volcanoes in Antarctica, with more than 20 explosive eruptive events registered over the past centuries. Recent eruptions (1967, 1969, and 1970) and volcanic unrest episodes (1992, 1999, and 2014–2015) demonstrate that volcanic activity is likely occurring in the future. This is of special concern for scientists, logistic personnel, ...

Background: Closed fitness centers during the Covid-19 pandemic may negatively impact health and wellbeing. We assessed whether training at fitness centers increases the risk of SARS-CoV-2 virus infection.<p> <p>Methods: In a two-group parallel randomized controlled trial, fitness center members aged 18 to 64 without Covid-19-relevant comorbidities, were randomized to access to training at a ...

The Norwegian welfare and labor market policy has as its focus to “get everyone at work”. Employers in ordinary companies are given a central role because ordinary work is seen both as a goal and as a method to get more people with disabilities at work. This article examines employers’ experiences and understandings of how they do the inclusive work, and how governance practices and institutional ...

The relative contribution of bryophytes to plant diversity, primary productivity, and ecosystem functioning increases towards colder climates. Bryophytes respond to environmental changes at the species level, but because bryophyte species are relatively difficult to identify, they are often lumped into one functional group. Consequently, bryophyte function remains poorly resolved. Here, we explore ...

Feeding 3.9 and 6.7 mg Hg/kg (Se/Hg molar ratios of 0.8 and 0.4, respectively) for 14 days negatively afected Dicentrarchus labrax growth and total DNTB- and thioredoxin-reductase (TrxR) activities and the transcription of four redox genes (txn1, gpx1, txnrd3, and txnrd2) in the liver, but a diet with 0.5 mg Hg/kg (Se/Hg molar ratio 6.6) slightly increased both reductase activities and the ...

As species respond to warming water temperatures, fishers dependent upon such species are being compelled to make choices concerning harvest strategies. Should they “follow fish” to new fishing grounds? Should they change their mix of target species? Should they relocate their operations to new ports? We examined how fishing communities in the Northeast United States —a hotspot of recent warming—have ...

Antarctic marine benthic invertebrates are an underexplored source of natural products for biodiscovery. Bioactive marine natural products from Antarctica are reviewed here for their potential use as drugs, considering the main examples in Porifera (15 species), Cnidaria (eight species), Mollusca (one species), Bryozoa (one species), Nemertea (one species), Echinodermata (six species), and ...

Background: During procedures such as nephron sparing surgery, kidney transplantation and thorocoabdominal aorta aneurysm surgery the kidney is subjected to ischemia and reperfusion injury which may lead to loss of renal function. It has been proposed that an intermittent and brief repeated sequence of ischemia and reperfusion immediately after the main ischemic insult, known as ischemic postconditioning ...