Now showing items 22301-22320 of 37061

    • Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway 

      Storjord, Elin; Dahl, Jim André; Landsem, Anne; Ludviksen, Judith K; Karlsen, Marlene; Karlsen, Bård Ove; Brekke, Ole-Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-10)
      <i>Background</i>: Lifestyle factors, including a low intake of carbohydrates, dieting, alcohol consumption, cigarette smoking and stress are some of the possible triggers of attacks in acute intermittent porphyria (AIP). The influence of lifestyle factors, including energy intake, diet and alcohol consumption on the biochemical disease activity in AIP and biochemical nutritional markers were ...
    • Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects 

      Sæther, Thomas; Paulsen, Steinar M; Tungen, Jørn Eivind; Vik, Anders; Aursnes, Marius; Holen, Torgeir; Hansen, Trond Vidar; Nebb, Hilde Irene (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-18)
      Obesity and associated disorders such as metabolic syndrome and type 2 diabetes (T2D) have reached epidemic proportions. Several natural products have been reported as Peroxisome Proliferator-Activated Receptor (PPAR) agonists, functioning as lead compounds towards developing new anti-diabetic drugs due to adverse side effects of existing PPAR drugs. We recently isolated and identified (7E)-9-oxoh ...
    • No overdiagnosis in the Norwegian Breast Cancer Screening Program estimated by combining record linkage and questionnaire information in the Norwegian Women and Cancer study 

      Lund, Eiliv; Nakamura, Aurelie; Thalabard, Jean-Christophe (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-12)
      <i>Background</i>: The Norwegian Breast Cancer Screening Program (NBCSP) was implemented across the country in 2005 and has been criticised for potential ‘overdiagnosis’, i.e. a breast cancer diagnosis that otherwise would not have been detected or treated in a woman’s lifetime. We aimed to estimate overdiagnosis in the NBCSP based on the Norwegian Women and Cancer (NOWAC) study using both ...
    • Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe: towards a common nomenclature 

      Bender, Jennifer; Cattoir, Vincent; Hegstad, Kristin; Sadowy, Eva; Coque, Teresa M.; Westh, Henrik; Hammerum, Anette M.; Schaffer, Kirsten; Burns, Karen; Murchan, Stephen; Novais, Carla; Freitas, Ana R.; Peixe, Luísa; Del Grosso, Maria; Pantosti, Annalisa; Werner, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-02)
      Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and ...
    • Psychological distance of climate change and mental health risks assessment of smallholder farmers in Northern Ghana: Is habituation a threat to climate change? 

      Acharibasam, Jeremiah Wezanamo; Anuga, Samuel Weniga (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-06)
      Although strong evidence shows climate change has physical impacts on human health, the mental health impacts appear unclear. The study aims to understand and explain the dynamic correlates between climate change and farmers’ emotional regulation practices, given psychological distance. Using 180 smallholder farmers in Northern Ghana, structural equation linear regression analysis showed that ...
    • Reproducibility and repeatability of six high-throughput 16S rDNA sequencing protocols for microbiota profiling 

      Raju, Sajan C.; Lagström, Sonja; Ellonen, Pekka; de Vos, Willem M.; Eriksson, Johan Gunnar; Weiderpass, Elisabete; Rounge, Trine Ballestad (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-18)
      Culture-independent molecular techniques and advances in next generation sequencing (NGS) technologies make large-scale epidemiological studies on microbiota feasible. A challenge using NGS is to obtain high reproducibility and repeatability, which is mostly attained through robust amplification. We aimed to assess the reproducibility of saliva microbiota by comparing triplicate samples. The ...
    • Inhalant use in adolescents in northern Russia 

      Koposov, Roman A; Stickley, Andrew; Ruchkin, Vladislav (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-02)
      <i>Purpose</i>: To determine the prevalence of inhalant use in Russian adolescents and to investigate associated psychosocial problems from a gender perspective. <p> <p><i>Methods</i>: Data on inhalant use and comorbid psychopathology were collected by means of self-reports from 2892 (42.4% boys) sixth to tenth grade students in public schools in Arkhangelsk, Russia. Multivariate analysis of ...
    • Racial Variation in Echocardiographic Reference Ranges for Left Chamber Dimensions in Children and Adolescents: A Systematic Review 

      Majonga, Edith D.; Norrish, Gabrielle; Rehman, Andrea M.; Kranzer, Katharina; Mujuru, Hilda A.; Nathoo, Kusum; Odland, Jon Øyvind; Kaski, Juan P.; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-04)
      Abstract Echocardiography plays a critical role in the assessment of cardiac disease. Important differences in echocardiographically derived cardiac chamber dimensions have been previously highlighted in different population groups in adult studies, but this has not been systematically studied in children, whose body size changes throughout childhood. The aim of this study was to review the ...
    • Temperamental adaptability, persistence, and regularity: Parental ratings of Norwegian infants aged 6 to 12 months, with some implications for preventive practice 

      Olafsen, Kåre Sten; Ulvund, Stein Erik; Torgersen, Anne Mari; Wentzel-Larsen, Tore; Smith, Lars; Moe, Vibeke (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-24)
      There is a need for standardized measures of infant temperament to strengthen current practices in prevention and early intervention. The present study provides Norwegian data on the Cameron‐Rice Infant Temperament Questionnaire (CRITQ; J.R. Cameron & D.C. Rice, 1986a), which comprises 46 items and is used within a U.S. health maintenance organization. The CRITQ was filled out by mothers and fathers ...
    • Rethinking the carcinogenesis of breast cancer: The theory of breast cancer as a child deficiency disease or a pseudo semi-allograft 

      Lund, Eiliv; Busund, Lill-Tove Rasmussen; Thalabard, Jean-Christophe (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-23)
      The theory of breast cancer as a <i>child deficiency disease</i> is an <i>inversion of the current paradigm</i>, which considers fullterm pregnancies to be a protective factor and uses nulliparous women as the reference group. Instead, the theory of breast cancer as a child deficiency disease says that women with the highest parity (about 20, which is the limit of human fertility) are those with ...
    • Sex- and sex hormone-related variations in energy-metabolic frontal brain asymmetries: A magnetic resonance spectroscopy study 

      Hjelmervik, Helene; Hausmann, Markus; Craven, Alexander R.; Hirnstein, Marco; Hugdahl, Kenneth; Specht, Karsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-31)
      Creatine is a key regulator of brain energy homeostasis, and well-balanced creatine metabolism is central in healthy brain functioning. Still, the variability of brain creatine metabolism is largely unattended in magnetic resonance spectroscopy (MRS) research. In the human brain, marginal sex differences in creatine levels have been found in the prefrontal cortex. It is however not known to ...
    • Understanding Pain and Pain Management in Elderly Nursing Home Patients Applying an Interprofessional Learning Activity in Health Care Students: A Norwegian Pilot Study 

      Damsgård, Elin; Solgård, Hege; Johannessen, Karin; Wennevold, Katrine; Kvarstein, Gunnvald; Pettersen, Gunn; Garcia, Beate Hennie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-18)
      <p><i>Background - </i>Pain is common among elderly patients in nursing homes. However, pain assessment and treatment are inadequate. Interprofessional treatment is recommended, and consequently interprofessional education in pain management is necessary. <p><i>Aims - </i>This pilot project aimed to describe how two interprofessional groups of students approached pain management in two nursing ...
    • The construction of new scientific norms for solving Grand Challenges 

      Maxwell, Kate; Benneworth, Paul (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-01)
      There is an increasing recognition that there is a class of problems that society must solve urgently in the twenty-first century if humanity is to survive into the twentysecond century—the so-called ‘Grand Challenges’. Science policymakers have been active in recognising these challenges and the attendant need to develop new multidisciplinary ways of working. But embracing multidisciplinarity ...
    • A new five-wavelength photometer operated in Tromsø (69.6°N, 19.2°E) 

      Nozawa, Satonori; Kawabata, Tetsuya; Hosokawa, Keisuke; Ogawa, Yasunobu; Tsuda, Takuo; Mizuno, Akira; Fujii, Ryoichi; Hall, Chris (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-11)
      A new fve-wavelength photometer was developed and installed at the EISCAT Tromsø site (69.6°N, 19.2°E) in January 2017. The photometer consists of two units: an optical unit and a control unit together with a PC. The photometer is capable of simultaneously observing auroral emissions with fve wavelengths. A uniqueness of the present system is its capability of precise pointing, which enables ...
    • The Potential Usefulness of Virtual Reality Systems for Athletes: A Short SWOT Analysis 

      Düking, Peter; Holmberg, Hans-Christer; Sperlich, Billy (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-05)
      Virtual reality (VR) systems (Neumann et al., 2017), which are currently receiving considerable attention from athletes, create a two- or three-dimensional environment in the form of emulated pictures and/or video-recordings where in addition to being mentally present, the athlete even often feels like he/she is there physically as well. As she/he interacts with and/or reacts to this environment, ...
    • Samarbeid om tiltak ved bekymring for elever i skolen 

      Haugen, Vivian D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019)
      Alle lærere som jobber i skolen opplever fra tid til annen bekymring for elever som av en eller annen grunn ikke greier å tilpasse seg klassen på en hensiktsmessig måte, eller som ikke utvikler seg i den retning en forventer. Det kan være flere forhold som kan bekymre en lærer. Utgangspunktet kan være at eleven tilkjennegir små og ganske diffuse signaler i form av tiltagende utagering eller at ...
    • Bruk av medikamenter for alkoholbrukslidelser i Norge 2004–16 

      Heldal, Anne Taraldsen; Skurtveit, Svetlana; Lobmaier, Philipp Paul K.; Vederhus, John-Kåre; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-08)
      <p><i>Bakgrunn - </i>Alkoholbrukslidelser forårsaker alvorlig sykelighet og tidlig død. Livstidsprevalens estimeres til 7–10 % i den norske befolkningen. Mange pasienter kommer ikke inn i behandlingsapparatet, og det antas at få av dem som kommer i behandling får medikamentell behandling. På markedet er det flere medikamenter som kan hjelpe til med å redusere mengde inntatt alkohol og å opprettholde ...
    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-27)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) of AD cases and controls of European descent from the multi-center DemGene network across Norway and two independent European cohorts. In a two-stage process, we first performed ...
    • Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders 

      Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Melle, Ingrid; Agartz, Ingrid; Andreassen, Ole Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-17)
      <p><i>Background - </i>Although several studies have found reduced plasma BDNF levels in patients with severe mental disorders, the sample sizes have been small and have exhibited variation and heterogeneity. Furthermore, long-term neurobiological changes following childhood trauma and clinical severity have been linked to a reduction in BDNF levels. Accordingly, we aim to clarify, using the largest ...
    • Kritisk pedagogikk – et svar på dagens kunstpedagogiske utfordringer? 

      Strobelt, Michael (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-27)
      Artikkelen undersøker opprinnelsen og utviklingen av den kritiske pedagogikken og dens relevans for kunstnerisk utdanning i dag. Innledningsvis skisseres kunstfagenes vilkår i dagens utdanningslandskap, som er preget av nyliberal instrumentell tenkning og med økende krav om økonomisering, standardisering og målstyring. Ut fra en oppfatning om at mange av dagens utdanningspolitiske føringer strider ...