Although chronic myeloid leukemia (CML) can be effectively treated using BCR‑ABL1 kinase inhibitors, resistance due to kinase alterations or to BCR‑ABL1 independent mechanisms remain a therapeutic challenge. For the latter, the underlying mechanisms are widely discussed; for instance, gene expression changes, epigenetic factors and alternative signaling pathway activation. In the present study, in ...

The study of the Finnish language – called Fennistics – was focused on collecting Finnish dialect material from very early on. During the 19th century interest in studying dialects was governed by the idea that dialects could be used to develop modern written Finnish. However, gradually the study of dialects also became an area of study in its own right. Collecting material on Kven dialects belonged ...

The prognosis of cutaneous melanoma depends on early detection, and good biomarkers for melanoma risk may provide a valuable tool to detect melanoma development at a pre-clinical stage. By studying the epigenetic profile in pre-diagnostic blood samples of melanoma cases and cancer free controls, we aimed to identify DNA methylation sites conferring melanoma risk. DNA methylation was measured at ...

Objectives - In this cross-sectional study from Botswana, we investigated awareness of calling emergency medical services (EMS) and seeking immediate medical assistance by acute stroke among stroke risk outpatients and public.<p> <p>Method - Closed-ended questionnaires on awareness of calling EMS and seeking immediate medical assistance by acute stroke, were administered by research assistants ...

Denne artikkelen tar utgangspunkt i en samling objekter som hovedsakelig ble samlet inn av den samiske kunstneren Iver Jåks (1932–2007). Nordnorsk Kunstmuseum har som eier av disse objektene definert dem som ett verk i museets samling og gjennom museets kuratoriske praksiser, til tross for at kunstneren ikke selv har satt de sammen eller tilvirket alle delene. Artikkelforfatteren fikk selv i oppdrag ...

Computational methods are increasingly used to support interpreting, assigning and predicting the solid-state nuclear resonance magnetic spectra of materials. Currently, density functional theory is seen to achieve a good balance between efficiency and accuracy in solid-state chemistry. To be specific, density functional theory allows the assignment of signals in nuclear resonance magnetic spectra ...

<p><b> Objective</b> To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks. <p><b> Setting</b> All neonatal intensive care units (NICUs) in Norway during 2012–2018. <p><b> Methods</b> Defined population-based data were prospectively entered into a national registry. We ...

In this study, we explore Indigenous energy opposition to and acceptance of small hydropower development. In Sapmi ´ (i.e., the traditional homeland of the Indigenous S´ ami people), land development poses a major threat to the cultural and material needs of the S´ ami people through the loss of pastures essential to Sami ´ reindeer herding. In contrast to large-scale renewable energy projects ...

Background: The lungs are the organ most likely to sustain serious injury from coronavirus disease 2019 (COVID-19). However, the mechanisms for long-term complications are not clear. Patients with severe COVID-19 have shorter telomere lengths and higher levels of cellular senescence, and we hypothesized that circulating levels of the telomere-associated senescence markers chitotriosidase, ...

There is ample evidence regarding positive health effects of cycling or walking to work (active commuting [AC]). However, little is known about the effects of AC on work ability. Therefore, we examined 422 Thai chicken meat industry workers who assessed their current work ability (CWA) compared to their lifetime best by assigning scores ranging from 0 to 10. The CWA was compared between active ...