Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in improving localized vaginal therapy by prolonging the residence time of a drug at ...

The brain as a drug target site remains a pharmaceutical challenge in spite of numerous efforts to enhance drug delivery to the brain. Nasal drug administration has gained interest among researchers, especially in the last decade, as it provides direct drug access into the brain. However, the nasal mucus and the surrounding environment often limit the use of nose as the administration site. Drug ...

Identifying resources driving long-term trends in predators is important to understand ecosystem changes and to manage populations in the context of conservation or control. The arctic fox population in Iceland has increased steadily over a period of 30 years, an increase that has been attributed to an overall increase in food abundance. We hypothesized that increasing populations of geese or seabirds ...

Melting of the Greenland Ice Sheet (GrIS) is the largest single contributor to eustatic sea level and is amplified by the growth of pigmented algae on the ice surface, which increases solar radiation absorption. This biological albedo-reducing effect and its impact upon sea level rise has not previously been quantified. Here, we combine field spectroscopy with a radiative-transfer model, supervised ...

Most patients whose large bowel cancer has spread to other organs do not respond to immune therapy. We detected a rare gene mutation, termed 9p24.1 copy-number gain (CNG), in an otherwise incurable colorectal cancer that provoked an immune therapy response. We identified this gene mutation by gene-panel sequencing of DNA from a liver metastasis biopsy from a patient who had disease refractory to ...

The aim of this paper is to re-activate certain layers of normative meaning that have been obscured, forgotten or rendered inoperative by the predominant traditions that engaged, from Grotius onwards, with the concept of <i>res communes omnium</i>. The hope and the purpose is that of offering a novel perspective on matters such as the protection and preservation of ocean commons that are of great ...

I Norge er det er et økende fokus på barns rett til å bli hørt ved obligatorisk mekling mellom foreldrene ved samlivsbrudd eller før foreldretvistsaker i domstolen. For å inkludere barn i meklingsarbeid er det utviklet flere modeller. En av disse er meklingsmodellen Barn i mekling (BIM). I BIM-modellen har barnet en egen samtale med mekler før meklingen gjennomføres med foreldrene. Artikkelen bygger ...

<i>Objective</i> - Evidence indicates that the pathophysiology of adult psychosis involves immune dysregulation, but its associations with stress are often not considered. The inflammatory cytokine interleukin (IL)-18, which is elevated in adult schizophrenia, is suggested to be sensitive to stress. We compared the associations of IL-18 with cortisol and clinical variables in adolescents with ...

<i>Importance</i> - No study, to our knowledge, has prospectively investigated a dose-response association between lifetime indoor tanning and risk of cutaneous squamous cell carcinoma (SCC).<p> <p><i>Objective</i> - To investigate the dose-response association between lifetime indoor tanning and SCC risk, the association between duration of use and age at initiation with SCC risk, and the ...

<i>Importance</i> - Aortic valve stenosis (AS) is the most common valve disease. Elevated levels of low-density lipoprotein (LDL) cholesterol are a risk factor; however, lipid-lowering treatment seems not to prevent progression of AS. The importance of LDL cholesterol in the development of AS thus remains unclear. People with familial hypercholesterolemia (FH) have elevated LDL cholesterol levels ...