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    • Performance and Design Study of Optimized LNG Mixed Fluid Cascade Processes 

      Brodal, Eivind; Jackson, Steven; Eiksund, Oddmar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
      Mixed Fluid Cascade (MFC) processes are often claimed to be one of the most efficient methods to liquefy natural gas. Their performance depends on both operating conditions such as ambient temperature, and system design parameters such as exchanger sizes. The performance of the standard MFC process can be further improved by modifying the design with additional equipment, such as liquid refrigerant ...

    • A first fecundity study of the female snow crab Chionoecetes opilio Fabricius, 1788 (Decapoda: Brachyura: Oregoniidae) of the newly established population in the Barents Sea 

      Danielsen, Hanna Ellerine Helle; Hjelset, Ann Merete; Bluhm, Bodil; Hvingel, Carsten; Agnalt, Ann-Lisbeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-11)
      The snow crab <i>Chionoecetes opilio</i> Fabricius, 1788 is a newly established species in the Barents Sea. Since the first individuals were recorded in 1996, the population has increased and a fishery was initiated in 2012. Mature female snow crab caught in the central Barents Sea were investigated with regards to fecundity. Ovigerous females (<i>N</i> = 185) ranged from 48 to 100 mm carapace width ...

    • Effect of genetically low 25-hydroxyvitamin D on mortality risk: Mendelian randomization analysis in 3 large European cohorts 

      Aspelund, Thor; Grübler, Martin R.; Smith, Albert V.; Gudmundsson, Elias F.; Keppel, Martin; Cotch, Mary Frances; Harris, Tamara B.; Jorde, Rolf; Grimnes, Guri; Joakimsen, Ragnar Martin; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; März, Winfried; Kleber, Marcus E.; Tomaschitz, Andreas; Grove-Laugesen, Diana; Rejnmark, Lars; Swart, Karin M.A.; Brouwer, Ingeborg A.; Lips, Paul; van Schoor, Natasja M.; Sempos, Christopher T.; Durazo-Arvizu, Ramón A.; Škrabáková, Zuzana; Dowling, Kirsten G.; Cashman, Kevin D.; Kiely, Mairead; Pilz, Stefan; Gudnason, Vilmundur; Eiríksdóttir, Gudny (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-02)
      The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D ...

    • Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model 

      Camilio, Ketil Andre; Wang, Meng-Yu; Mauseth, Brynjar; Waagene, Stein; Kvalheim, Gunnar; Rekdal, Øystein; Sveinbjørnsson, Baldur; Mælandsmo, Gunhild M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
      <i>Background</i> - Immunochemotherapy, the combined use of immunotherapy and chemotherapy, has demonstrated great promise in several cancers. LTX-315 is an oncolytic peptide with potent immunomodulatory properties designed for the local treatment of solid tumors. By inducing rapid immunogenic cell death through the release of danger-associated molecular pattern molecules (DAMPs), LTX-315 is capable ...

    • Closely-related Photobacterium strains comprise the majority of bacteria in the gut of migrating Atlantic cod (Gadus morhua) 

      Le Doujet, Typhaine; De Santi, Concetta; Klemetsen, Terje; Hjerde, Erik; Willassen, Nils Peder; Haugen, Peik (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-17)
      <p><i>Background - </i>The population of Atlantic cod (<i>Gadus morhua</i>), also known as Northeast Arctic cod, migrating Atlantic cod, or simply “skrei,” lives mainly in the Barents Sea and Svalbard waters and migrates in annual cycles to the Norwegian coast in order to spawn eggs during late winter. It is the world’s largest population of Atlantic cod, and the population is distinct from the ...

    • Sannhetskommisjoner. Om institusjonalisert kunnskap, kritisk distanse og andre antropologiske utfordringer 

      Saugestad, Sidsel (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-20)
      Denne artikkelen ser på noen aspekter av en sannhetskommisjon som er oppnevnt i Norge. Den første delen skisserer bakgrunnen for oppnevnelsen og diskuterer de argumentene som ble fremlagt, supplert med sitater fra en avisdebatt. Den andre delen setter denne debatten inn i en bredere sammenheng av norsk-samiske relasjoner og gir noen eksempler på samisk kommunikasjon om rett til å være forskjellig. ...

    • Pain-relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice 

      Hansson, Per; Jensen, Troels Staehelin; Kvarstein, Gunnvald; Strömberg, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-01)
      <p><i>Context - </i>Clinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. <p><i>Objective - </i>To determine whether treatment and re‐treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. <p><i>Methods - </i>Three ...

    • Improved Environmental Status: 50 Years of Declining Fish Mercury Levels in Boreal and Subarctic Fennoscandia 

      Braaten, Hans Fredrik Veiteberg; Åkerblom, Staffan; Kahilainen, Kimmo Kalevi; Rask, Martti; Vuorenmaa, Jussi; Mannio, Jaakko; Malinen, Tommi; Lydersen, Espen; Poste, Amanda; Amundsen, Per-Arne; Kashulin, Nikolai; Kashulina, Tatiana; Terentjev, Petr; Christensen, Guttorm; de Wit, Heleen (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-14)
      Temporally (1965–2015) and spatially (55°–70°N) extensive records of total mercury (Hg) in freshwater fish showed consistent declines in boreal and subarctic Fennoscandia. The database contains 54 560 fish entries (n: pike > perch ≫ brown trout > roach ≈ Arctic charr) from 3132 lakes across Sweden, Finland, Norway, and Russian Murmansk area. 74% of the lakes did not meet the 0.5 ppm limit to protect ...

    • Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer (NOWAC) study 

      Moi, Line; Braaten, Tonje; Al-Shibli, Khalid; Lund, Eiliv; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-03)
      <i>Background</i> - MicroRNAs (miRNAs) are promising biomarkers due to their structural stability and distinct expression profile in various cancers. We wanted to explore the miRNA expression in benign breast tissue and breast cancer subgroups in the Norwegian Women and Cancer study.<p> <p><i>Methods</i> - Specimens and histopathological data from study participants in Northern Norway diagnosed ...

    • A novel scale-space approach for multinormality testing and the k-sample problem in the high dimension low sample size scenario 

      Hindberg, Kristian; Hannig, Jan; Godtliebsen, Fred (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-22)
      Two classical multivariate statistical problems, testing of multivariate normality and the <i>k</i>-sample problem, are explored by a novel analysis on several resolutions simultaneously. The presented methods do not invert any estimated covariance matrix. Thereby, the methods work in the High Dimension Low Sample Size situation, i.e. when <i>n</i> ≤ <i>p</i>. The output, a significance map, is ...

    • Allodia Winnertz from the Himalayas, with nine species new to science (Diptera, Mycetophilidae). 

      Magnussen, Trude; Søli, Geir Einar Ellefsen; Kjærandsen, Jostein (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-29)
      An extensive collection of fungus gnats from Nepal and Bhutan, deposited at Kyushu University Museum in Japan, has been examined and revealed nine species of <i>Allodia</i> Winnertz, 1864 new to science: <i>Allodia caligata</i> Magnussen, <b>sp. n.</b>, <i>A. dibolia</i> Magnussen, <b>sp. n.</b>, <i>A. shimai</i> Magnussen, <b>sp. n.</b>, <i>A. spathulata</i> Magnussen, <b>sp. n.</b>, <i>A. horologia</i> ...

    • Transcriptomic analysis reveals dose-dependent modes of action of benzo(a)pyrene in polar cod (Boreogadus saida) 

      Song, You; Nahrgang, Jasmine; Tollefsen, Knut Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-21)
      Polar cod (<i>Boreogadus saida</i>) has been used as a model Arctic species for hazard assessment of environmental stressors such as polycyclic aromatic hydrocarbons (PAHs). However, most of the PAH studies using polar cod rely on targeted biomarker-based analysis thus may not adequately address the complexity of the toxic mechanisms of the stressors. The present study was performed to develop a ...

    • SKIM, a Candidate Satellite Mission Exploring Global Ocean Currents and Waves 

      Ardhuin, Fabrice; Brandt, Peter; Gaultier, Lucile; Donlon, Craig James; Battaglia, Alessandro; Boy, Francois; Casal, Tania; Chapron, Bertrand; Collard, Fabrice; Cravatte, Sophie; Delouis, Jean-Marc; De Witte, Erik; Dibarboure, Gerald; Engen, Geir; Johnsen, Harald; Lique, Camille; López-Dekker, Paco; Maes, Christophe; Martin, Adrien; Marie, Louis; Menemenlis, Dimitris; Nouguier, Frederic; Peureux, Charles; Rampal, Pierre; Ressler, Gerhard; Rio, Marie-Helene; Rommen, Bjorn; Shutler, Jamie D.; Suess, Martin; Tsamados, Michel; Ubelmann, Clement; van Sebille, Erik; van den Oever, Martin; Stammer, Detlef (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-30)
      The Sea surface KInematics Multiscale monitoring (SKIM) satellite mission is designed to explore ocean surface current and waves. This includes tropical currents, notably the poorly known patterns of divergence and their impact on the ocean heat budget, and monitoring of the emerging Arctic up to 82.5°N. SKIM will also make unprecedented direct measurements of strong currents, from boundary currents ...

    • Persistence of disseminated tumor cells after neoadjuvant treatment for locally advanced breast cancer predicts poor survival 

      Mathiesen, Randi Margit Ruud; Borgen, Elin; Renolen, Anne; Løkkevik, Erik; Nesland, Jahn M; Anker, Gun Birgitta; Østenstad, Bjørn; Lundgren, Steinar; Risberg, Terje; Mjaaland, Ingvil; Kvalheim, Gunnar; Lønning, Per Eystein; Naume, Bjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-08-14)
      <i>Introduction</i> - Presence of disseminated tumor cells (DTCs) in bone marrow (BM) and circulating tumor cells (CTC) in peripheral blood (PB) predicts reduced survival in early breast cancer. The aim of this study was to determine the presence of and alterations in DTC- and CTC-status in locally advanced breast cancer patients undergoing neoadjuvant chemotherapy (NACT) and to evaluate their ...

    • Kartlegging av prosedyrer for oppdekking av instrumentbord ved kirurgiske inngrep 

      Igesund, Unni; Rasmussen, Guri; Overvåg, Grete; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel, 2019)
      <p><i>Bakgrunn - </i>Operasjonspasienten og operasjonsteamet settes i en kalkulert risikosituasjon under en operasjon. Sikkert teamarbeid, arbeidsprosesser med kvalitetssikrede prosedyrer og anvendelse av sikkerhetsutstyr kan redusere komplikasjoner og skader. <p><i>Hensikt - </i>Studiens hensikt var å oppnå beste praksis og unngå uheldige hendelser i forbindelse med oppdekking og organisering av ...

    • Data-driven blood glucose pattern classification and anomalies detection: Machine-learning applications in Type 1 diabetes 

      Woldaregay, Ashenafi Zebene; Årsand, Eirik; Botsis, Taxiarchis; Albers, David; Mamykina, Lena; Hartvigsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-01)
      <p><i>Background - </i>Diabetes mellitus is a chronic metabolic disorder that results in abnormal blood glucose (BG) regulations. The BG level is preferably maintained close to normality through self-management practices, which involves actively tracking BG levels and taking proper actions including adjusting diet and insulin medications. BG anomalies could be defined as any undesirable reading ...

    • Bipolar radiofrequency neurotomy for spinal pain - A promising technique but still some steps to go 

      Kvarstein, Gunnvald; Lundeland, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-02)

    • Prepositional Phrase Attachment Ambiguities in German. A Cross-Dialectal Experimental Study 

      Pilsbacher, Anna Katharina (Master thesis; Mastergradsoppgave, 2018-05-15)
      This thesis addresses the production and perception of sentences with ambiguous prepositional phrase attachment in Standard German. In the first part of the study, an informed native speaker produced prosodically disambiguated sentences, which were analysed acoustically for disambiguation cues. In the second part, these sentences were then presented in a perception test where respondents were asked ...

    • p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance 

      Flem-Karlsen, Karine; Tekle, Christina; Øyjord, Tove Ragnhild; Flørenes, Vivi Ann; Mælandsmo, Gunhild Mari; Fodstad, Øystein; Nunes-Xavier, Caroline Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-09)
      Immunoregulatory protein B7-H3 is involved in the oncogenic and metastatic potential of cancer cells, as well as in drug resistance. Resistance to conventional chemotherapy is an important aspect of melanoma treatment, and a better understanding of how B7-H3 enhances drug resistance may lead to the development of more effective therapies. We investigated the <i>in vitro</i> and <i>in vivo</i> ...

    • An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression 

      Haider, Zahra; larsson, Pär; Landfors, Mattias; Kohn, Linda; Schmiegelow, Kjeld; Flægstad, Trond; Kanerva, Jukka; Heyman, Mats; Hultdin, Magnus; Degerman, Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-21)
      Classification of pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients into CIMP (CpG Island Methylator Phenotype) subgroups has the potential to improve current risk stratification. To investigate the biology behind these CIMP subgroups, diagnostic samples from Nordic pediatric T-ALL patients were characterized by genome-wide methylation arrays, followed by targeted exome sequencing, ...