The Wnt signaling pathway plays a crucial role in neurodevelopment and in regulating the function and structure of the adult nervous system. Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders with evidence of subtle neurodevelopmental, structural and functional neuronal abnormalities. We aimed to elucidate the role of aberrant regulation of the Wnt system in these disorders ...

Sepsis fra bakterier er en alvorlig tilstand som årlig krever mange liv. Selv om immunsystemet og det hemostatiske system samarbeider for å bekjempe bakterieinfeksjoner, kan dette i noen tilfelle skyte over mål. Derfor har vi i denne studien undersøkt om bakterieindusert aktivering av koagulasjon og inflammasjon reduseres av en dobbelthemming av komplementsystemet og toll-like reseptorer (TLR). Det ...

This systematic review revealed and discussed empirical evidence generated from 21 international user-driven innovation studies in the public health and social care. We used PRISMA guideline to ensure a transparent and replicable research process. With the guide of relevant theoretical models, we identified the distinct characteristics of user-driven innovation in current public social care sectors, ...

Social-ecological systems (SES) consist of a social and an ecological system that are linked through a complex interplay of social and ecological processes. SES can be studied through SES research, which has become increasingly important because it is thought that it can potentially address and solve many societal challenges, such as climate change, resource scarcity, and habitat degradation. SES ...

A series of column leaching experiments were performed to understand the leaching behavior of Co, Fe and Ni in Ballangen mine tailings. Multivariate statistical approaches to evaluate potential risk variations in leachate quality and identifies temperature effects on their leaching behavior. Results from column leaching test indicated that the mobility of showed higher temperature may encourage ...

<i>Introduction</i>: The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid (Aβ) clearance. We hypothesize that increased Ng/BACE1 ratio predicts the earliest cognitive decline in Alzheimer’s disease.<p> <p><i>Methods</i>: We compared Ng/BACE1 levels between cases with subjective ...

<p>Background</i>: Cognitive assessment is essential in tracking disease progression in AD. Presently, cohorts including preclinical at-risk participants are recruited by different means, which may bias cognitive and clinical features. We compared recruitment strategies to levels of cognitive functioning.<p> <p><i>Objective</i>: We investigate recruitment source biases in self-referred and ...

Background: Alzheimer’s disease (AD) may develop 10-15 years before onset of mild cognitive impairment (MCI). Early intervention may serve to halt or delay disease progression. Thus, there is a need to investigate early cognitive and biological markers to detect and track disease progression. Subjective cognitive decline (SCD) is an established risk-factor for AD. However, SCD is a common phenomenon ...

A Commentary on <p> <p>Transcranial stimulation of the frontal lobes increases propensity of mind-wandering without changing meta-awareness<p> <p>by Axelrod, V., Zhu, X., & Qui, J. (2018). <i>Scientific Reports</i>, 8:15975. doi: 10.1038/s41598-018-34098-z

Here, female and male elite cross-country (XC) skiers were compared on varying terrain during an official 10-km (women) and 15-km (men) Norwegian championship race. On the basis of race performance, 82 skiers were classified as fast (FS) (20 women, 20 men) or slower (SS) (21, 21) skiers. All were video recorded on flat (0°), intermediate (3.5°), uphill (7.1°) and steep uphill (11°) terrain during ...