Ptarmigan are herbivorous birds that are year-round residents of alpine and arctic ecosystems — presently subjected to the most rapid climate warming on earth. Yet, compared to other bird taxa there has been little climate impact research on ptarmigan. Ptarmigan population dynamics, in particular in the sub/low-arctic, appears to be strongly influenced by complex interactions with a suite of ...

LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat fibrosarcoma model. The treatment was T-cell dependent, and also resulted in an abscopal effect as demonstrated by the regression of distal non-treated lesions. Significant infiltration ...

Background<br> Abdominal symptoms are diagnostically challenging to general practitioners (GPs): although common, they may indicate cancer. In a prospective cohort of patients, we examined abdominal symptom frequency, initial diagnostic suspicion, and actions of GPs in response to abdominal symptoms.<p> Methods<br> Over a 10-day period, 493 GPs in Norway, Denmark, Sweden, Belgium, the Netherlands, ...

Epitelial eggstokkreft (EEK) er den 6. mest vanlige kreftformen blant norske kvinner. Det diagnostiseres ca. 450 nye tilfeller per år. Fem års overlevelse har økt og det har derfor vært viktig å se på langtidseffektene som påvirker kvinnene. Kvinnene kommer i en umiddelbar menopause etter kirurgisk fjerning av eggstokkene. Dette gjør også at de ofte opplever mer symptomer og plager enn kvinner som ...

Introduction: Osteoporosis is characterized by decreased bone mineral density (BMD) and is a risk factor for hip, wrist, and vertebral fractures. Fragility fractures lead to increased mortality, morbidity, pain, immobility, social isolation and depression, which all may affect the quality of life (QoL). Use of anti-osteoporotic drugs (AOD) reduces the risk of fractures and may influence QoL. Objective: ...

BAKGRUNN: Avvik i legemiddelhåndteringen kan assosieres med lengre sykehusopphold og høyere helsekostnader, noe som medfører høy belastning for pasient, pårørende og helsevesen. Avviksrapportering belyser hvor det er læringspotensial og behov for forbedringstiltak. Avvik i helsevesenet skal innrapporteres og brukes som et ledd for å forbedre pasientsikkerheten, forebygge kvalitetssvikt og hindre ...

Submarine landslides are major agents of sediment mass transfer from the shallow to deep sea. Due to their rapid emplacement and tsunamigenic potential, such landslides are significant geohazards for society and off- and on-shore infrastructure. The relationship between climate change and the occurrence of submarine landslides is widely debated. However, there is a lack of continuous long-term ...

Autophagy is an essential cellular process that is important to maintain homeostasis by degrading proteins, lipids and organelles during critical times like cellular or environmental stress conditions. Autophagy plays a critical role in human pathologies, since defective autophagy can lead to diseases like cancer, neurodegenerative- and inflammatory diseases. Fez1 (Fasciculation and elongation protein ...

Life cycle assessment (LCA) is increasingly used for environmental assessment of products and production processes to support environmental decision-making both worldwide and in the Arctic. However, there are several weaknesses in the impact assessment methodology in LCA, e.g., related to uncertainties of impact assessment results, absence of spatial differentiation in characterization modeling, and ...

Denne oppgaven undersøker hvilke sammenhenger det er mellom offentlige lederes arbeidsmotivasjon og deres opplevde arbeidsytelse. Jeg ser nærmere på om lederne er indre- eller ytre motivert og hvordan lederne opplever egne prestasjoner. Arbeidsmotivasjon handler i denne oppgaven om indre og ytre krefter som initierer arbeidsrelatert atferd, mens arbeidsytelse er den forventede verdien fra de ansattes ...