Dynamic self-organisation of haematopoiesis and (a)symmetric cell division
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https://hdl.handle.net/10037/11425Dato
2016-12-05Type
Journal articleTidsskriftartikkel
Peer reviewed
Sammendrag
A model of haematopoiesis that links self-organisation with symmetric and asymmetric cell division is presented
in this paper. It is assumed that all cell divisions are completely random events, and that the daughter cells
resulting from symmetric and asymmetric stem cell divisions are, in general, phenotypically identical, and still,
the haematopoietic system has the flexibility to self-renew, produce mature cells by differentiation, and
regenerate undifferentiated and differentiated cells when necessary, due to self-organisation. As far as we know,
no previous model implements symmetric and asymmetric division as the result of self-organisation. The model
presented in this paper is inspired by experiments on the Drosophila germline stem cell, which imply that under
normal conditions, the stem cells typically divide asymmetrically, whereas during regeneration, the rate of
symmetric division increases. Moreover, the model can reproduce several of the results from experiments on
female Safari cats. In particular, the model can explain why significant fluctuation in the phenotypes of
haematopoietic cells was observed in some cats, when the haematopoietic system had reached normal
population level after regeneration. To our knowledge, no previous model of haematopoiesis in Safari cats
has captured this phenomenon.