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3,4-Dihydroquinoxalin-2-ones: recent advances in synthesis and bioactivities

Permanent link
https://hdl.handle.net/10037/12844
DOI
https://doi.org/10.1007/s10593-017-2052-6
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Accepted manuscript version (PDF)
Date
2017-04-26
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Kristoffersen, Tone; Hansen, Jørn H.
Abstract
A summary of recent synthesis approaches to 3,4-dihydroquinoxaline-2-ones is discussed herein along with highlights of biological activity. The synthetic approaches include access to enantiopure heterocycles from chiral pool amino acids via coupling/cyclization, Michael addition/cyclization cascades, 3,3-disubstituted systems from multicomponent couplings, Bargellini reaction or photochemical reduction. The heterocycle displays notable antiviral and anti-inflammatory activities.
Description
This is a post-peer-review, pre-copyedit version of an article published in Chemistry of Heterocyclic Compounds. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10593-017-2052-6.
Publisher
Springer Verlag
Citation
Kristoffersen, T. & Hansen, J. H. (2017). 3,4-Dihydroquinoxalin-2-ones: recent advances in synthesis and bioactivities. Chemistry of Heterocyclic Compounds, 53(3), 310-312. http://doi.org/10.1007/s10593-017-2052-6
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