3,4-Dihydroquinoxalin-2-ones: recent advances in synthesis and bioactivities
A summary of recent synthesis approaches to 3,4-dihydroquinoxaline-2-ones is discussed herein along with highlights of biological activity. The synthetic approaches include access to enantiopure heterocycles from chiral pool amino acids via coupling/cyclization, Michael addition/cyclization cascades, 3,3-disubstituted systems from multicomponent couplings, Bargellini reaction or photochemical reduction. The heterocycle displays notable antiviral and anti-inflammatory activities.
This is a post-peer-review, pre-copyedit version of an article published in Chemistry of Heterocyclic Compounds. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10593-017-2052-6.