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Synthesis of Indoles and Pyrroles Utilizing Iridium Carbenes Generated from Sulfoxonium Ylides

Permanent lenke
https://hdl.handle.net/10037/13140
DOI
https://doi.org/10.1002/anie.201610520
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article.pdf (1.169Mb)
Accepted manuscript version (PDF)
Dato
2017-03-20
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Vaitla, Janakiram; Bayer, Annette; Hopmann, Kathrin Helen
Sammendrag
Metal carbenes can undergo a myriad of synthetic transformations. Sulfur ylides are potential safe precursors of metal carbenes. Herein, we report cascade reactions that involve carbenoids derived from sulfoxonium ylides for the efficient and regioselective synthesis of indoles and pyrroles. The tandem action of iridium and Brønsted acid catalysts enables rapid assembly of the heterocycles from unmodified anilines or readily accessible enamines under microwave irradiation. The key mechanistic steps are the catalytic transformation of the sulfoxonium ylide into an iridium–carbene complex, followed by N−H or C−H functionalization of an aniline or enamine, respectively, and a final acid‐catalyzed cyclization. The present method was successfully applied to the synthesis of the densely functionalized pyrrole subunit of atorvastatin.
Beskrivelse
Accepted manuscript version. Published version available at https://doi.org/10.1002/anie.201610520.
Forlag
Wiley
Sitering
Vaitla, J., Bayer, A. & Hopmann, K.H. (2017). Synthesis of Indoles and Pyrroles Utilizing Iridium Carbenes Generated from Sulfoxonium Ylides. Angewandte Chemie International Edition, 56(15), 4277-4281. https://doi.org/10.1002/anie.201610520
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