The molecular origin of cold adaptation: A comparative study of cold- and warm-active uracil DNA glycosylase
Paper I: Moe, E., Leiros, I., Riise, E.K., Olufsen, M., Lanes, O., Smalås, A.O. & Willassen, N.P. (2004). Optimisation of the Surface Electrostatics as a Strategy for Cold Adaptation of Uracil-DNA N-glycosylase (UNG) from Atlantic Cod (Gadus morhua). (Article in press). The article is available in the thesis introduction. Published version in Journal of Molecular Biology, 343(5), 1221-1230, is available at https://doi.org/10.1016/j.jmb.2004.09.004.
Paper II: Olufsen, M., Smalås, A.O., Moe, E. & Brandsdal, B.O. (2005). Increased flexibility as a strategy for cold adaptation – A comparative molecular dynamics study of cold- and warm-active uracil DNA glycosylase. Journal of biological chemistry, 280, 18042-18048. Also available at https://doi.org/10.1074/jbc.M500948200.
Paper III: Olufsen, M., Brandsdal, B.O. & Smalås, A.O. (2007). Comparative unfolding studies of psychrophilic and mesophilic uracil DNA glycosylase: MD simulations show reduced thermal stability of the cold-adapted enzyme. (Article in press). The article is available in the thesis introduction. Published version in Journal of Molecular Graphics and Modelling, 26(1), 124-134, is available at https://doi.org/10.1016/j.jmgm.2006.10.003. .
Paper IV Olufsen, M., Papaleo, E., Smalås, A.O. & Brandsdal, B.O. Ion pairs and their role in modulating stability of cold- and warm-active uracil DNA glycosylase. (Submitted manuscript). Published version in Proteins, 71(3), 1219-1230, is available at https://doi.org/10.1002/prot.21815.
Paper V: Olufsen, M., Smalås, A.O. & Brandsdal, B.O. Electrostatic interactions play an essential role in DNA repair and cold-adaptation of Uracil DNA Glycosylase. (Manuscript). Published version in Journal of Molecular Modeling, 14(3), 201-213, is available at https://doi.org/10.1007/s00894-007-0261-0.
PublisherUniversitetet i Tromsø
University of Tromsø
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