Blar i forfatter Artikler, rapporter og annet (kjemi) "Anderssen, Trude"

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    • Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character 

      Paulsen, Marianne Hagensen; Ausbacher, Dominik; Bayer, Annette; Engqvist, Magnus; Hansen, Terkel; Haug, Tor; Anderssen, Trude; Andersen, Jeanette Hammer; Sollid, Johanna U. Ericson; Strøm, Morten B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-06)
      The rapid emergence and spread of multi-resistant bacteria have created an urgent need for new antimicrobial agents. We report here a series of amphipathic α,α-disubstituted β-amino amide derivatives with activity against 30 multi-resistant clinical isolates of Gram-positive and Gram-negative bacteria, including isolates with extended spectrum β-lactamase – carbapenemase (ESBL-CARBA) production. A ...

    • A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile 

      Langer, Manuel K; Rahman, Ataur; Dey, Hymonti; Anderssen, Trude; Zilioli, Francesco; Haug, Tor; Blencke, Hans-Matti; Stensvåg, Klara; Strøm, Morten B.; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-05)
      An amphipathic barbiturate mimic of the marine eusynstyelamides is reported as a promising class of antimicrobial agents. We hereby report a detailed analysis of the structure-activity relationship for cationic amphipathic N,N′ -dialkylated-5,5-disubstituted barbiturates. The influence of various cationic groups, hydrocarbon linkers and lipophilic side chains on the compounds’ antimicrobial potency ...

    • Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties 

      Langer, Manuel K; Rahman, Ataur; Dey, Hymonti; Anderssen, Trude; Blencke, Hans-Matti; Haug, Tor; Stensvåg, Klara; Strøm, Morten B.; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-24)
      Mimics of antimicrobial peptides (AMPs) have been proposed as a promising class of antimicrobial agents. We report the analysis of five tetrasubstituted, cationic, amphipathic heterocycles as potential AMP mimics. The analysis showed that the heterocyclic scaffold had a strong influence on the haemolytic activity of the compounds, and the hydantoin scaffold was identified as a promising template for ...