Blar i forfatter Artikler, rapporter og annet (kjemi) "Bril'kov, Maxim"

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    • Goldilocks Dilemma: LPS Works Both as the Initial Target and a Barrier for the Antimicrobial Action of Cationic AMPs on E. coli 

      Jakubec, Martin; Rylandsholm, Fredrik G.; Rainsford, Philip; Silk, Mitchell; Bril'kov, Maxim; Kristoffersen, Tone; Juskewitz, Eric; Ericson, Johanna U; Svendsen, John Sigurd Mjøen (Journal article; Tidsskriftartikkel, 2023-07-20)
      Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically disrupt bacterial membranes. Despite extensive research, the precise mode of action of AMPs is still a topic of great debate. This work demonstrates that the initial interaction between the Gram-negative E. coli and AMPs is driven by lipopolysaccharides (LPS) that act as kinetic barriers for the binding of AMPs to ...