Blar i forfatter Artikler, rapporter og annet (kjemi) "Ericson, Johanna U"

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    • Goldilocks Dilemma: LPS Works Both as the Initial Target and a Barrier for the Antimicrobial Action of Cationic AMPs on E. coli 

      Jakubec, Martin; Rylandsholm, Fredrik G.; Rainsford, Philip; Silk, Mitchell; Bril'kov, Maxim; Kristoffersen, Tone; Juskewitz, Eric; Ericson, Johanna U; Svendsen, John Sigurd Mjøen (Journal article; Tidsskriftartikkel, 2023-07-20)
      Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically disrupt bacterial membranes. Despite extensive research, the precise mode of action of AMPs is still a topic of great debate. This work demonstrates that the initial interaction between the Gram-negative E. coli and AMPs is driven by lipopolysaccharides (LPS) that act as kinetic barriers for the binding of AMPs to ...

    • Label-free measurement of antimicrobial peptide interactions with lipid vesicles and nanodiscs using microscale thermophoresis 

      Rainsford, Philip; Rylandsholm, Fredrik G.; Jakubec, Martin; Silk, Mitchell; Juskewitz, Eric; Ericson, Johanna U; Svendsen, John Sigurd Mjøen; Engh, Richard Alan; Isaksson, Johan Mattias (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-03)
      One strategy to combat antimicrobial resistance is the discovery of new classes of antibiotics. Most antibiotics will at some point interact with the bacterial membrane to either interfere with its integrity or to cross it. Reliable and efficient tools for determining the dissociation constant for membrane binding (K<sub>D</sub>) and the partitioning coefficient between the aqueous- and membrane ...