Blar i forfatter Artikler, rapporter og annet (kjemi) "Flach, Carl-Fredrik"

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    • Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10 

      Leiros, Hanna-Kirsti S.; Thomassen, Ane Molden; Samuelsen, Ørjan; Flach, Carl-Fredrik; Kotsakis, Stathis D.; Larsson, Joakim (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-19)
      Carbapenemases are the main cause of carbapenem resistance in Gram‐negative bacteria. How β‐lactamases with weak carbapenemase activity, such as the OXA‐10‐type class D β‐lactamases, contribute to anti‐bacterial drug resistance is unclear. OXA‐655 is a T26M and V117L OXA‐10 variant, recently identified from hospital wastewater. Despite exhibiting stronger carbapenemase activity towards ertapenem ...