Blar i forfatter Artikler, rapporter og annet (kjemi) "Fugelli, Anders"

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    • DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes 

      Zhu, Bangfu; Parsons, Tom; Stensen, Wenche Gunvor Berg; Svendsen, John Sigurd Mjøen; Fugelli, Anders; Hodge, James W.L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-19)
      Alzheimer’s disease (AD) is the most common neurodegenerative disease which is becoming increasingly prevalent due to ageing populations resulting in huge social, economic, and health costs to the community. Despite the pathological processing of genes such as Amyloid Precursor Protein (APP) into Amyloid-β and Microtubule Associated Protein Tau (MAPT) gene, into hyperphosphorylated Tau tangles being ...

    • Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome 

      Stensen, Wenche; Rothweiler, Ulli; Engh, Richard Alan; Stasko, Melissa R.; Bederman, Ilya; Costa, Alberto C. S.; Fugelli, Anders; Svendsen, John Sigurd Mjøen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-17)
      Down syndrome (DS) is a complex genetic disorder associated with substantial physical, cognitive, and behavioral challenges. Due to better treatment options for the physical co-morbidities of DS, the life expectancy of individuals with DS is beginning to approach that of the general population. However, the cognitive deficits seen in individuals with DS still cannot be addressed pharmacologically. ...