A caesium fluoride-mediated hydrocarboxylation of olefins is disclosed that does not rely on precious transition metal catalysts and ligands. The reaction occurs at atmospheric pressures of CO₂ in the presence of 9-BBN as a stoichiometric reductant. Stilbenes, β-substituted styrenes and allenes could be carboxylated in good yields. The developed methodology can be used for preparation of ...

CO₂ is a promising and sustainable carbon feedstock for organic synthesis. New catalytic protocols for efficient incorporation of CO₂into organic molecules are continuously being reported. However, little progress has been made in the enantioselective conversion of CO₂to form enantioenriched molecules. In order to allow CO₂to become a versatile carbon ...

Phorbazoles are polychlorinated heterocyclic secondary metabolites isolated from a marine sponge and several of these natural products have shown inhibitory activity against cancer cells. In this work, a synthesis of the trichlorinated phorbazole B using late stage electrophilic chlorination was developed. The synthesis relied on the use of an oxazole precursor, which was protected with an iodine ...